PACAD · Psoriatic Arthrtis and Coronary Artery Disease
FP7 — People (Marie Curie Actions)
- Duration
- 2011-12-01 → 2015-06-30
- EU contribution
- €89,583
- Participants
- 1
- Scheme
- MC-IRG
Lines connect the coordinator with its partners.
Results in brief
Psoriatic Arthrtis and Coronary Artery Disease
Psoriatic arthritis is a multi-system auto-immune disease that affects approximately 0.15% of the adult European population. PACAD is a study that aims to investigate potential links between psoriatic arthritis and coronary artery disease. The project has received funding from the EU FP7 Marie Curie People program and is scheduled to complete in 2015. The project is currently on schedule with regards to data collection and analysis, and publication of results should be completed in 2016. The host institution will continue to support work on the project after the grant completion date. The objectives of the project involved using existing data sets in Iceland to compare the risk of cardiovascular disease in the general population to that seen among patients with psoriatic arthritis. The first objective was to understand the crude difference in cardiovascular disease between these groups. The second objective was to compare the risk factors profiles of these two groups. The third objective was to extract further information on cardiovascular risk factors from medical records. Information on risk factors for cardiovascular disease was more readily available in medical records than expected, and simpler methods than proposed could be used to extract more information than projected. This has allowed for a more detailed analysis, where objective two is merged in part with objective one to allow a fully adjusted model of cardiovascular disease in a nested study within objective one. The main result published from PACAD so far is that patients with PsA do not have a shortened lifespan compared to that seen in the general population. The fellow from the PACAD project has participated in a study of the British general population, which confirmed these results from PACAD. As soon as the analysis of cardiovascular risk factor and outcome data in PACAD is complete the results will be published as well. The impact of the final results will involve a better understanding of the comorbidities of PsA which will in turn inform physicians about how to best care for these patients. The results will therefore have a direct impact on society through the planning and provision of medical care in the European Union.
Data: CORDIS, © European Union
Project objective
Background:Psoriatic arthritis is a multi-system auto-immune disease that affects approximately 0.15% of European populations. It can result in lost productivity and a decreased quality of life. The skin disease psoriasis is associated with cardiovascular disease. This is also true for rheumatoid arthritis. Initial data suggest an association between psoriatic arthritis and heart disease, but no population based studies exist. We propose a multi-disciplinary study combining advanced information technology and a collaboration between experts in cardiology and rheumatology. The proposed study is population based and addresses an important clinical question.Objective:To confirm and quantify the association between psoriatic arthritis and cardiovascular disease in the general population.Methods:Detailed population level data are available from the Icelandic Heart Association’s registry of every case of myocardial infarction occurring in the Icelandic population since 1981. We have previously compiled a list of all known cases of psoriatic arthritis in Iceland and propose linking this list to the heart disease registry. We will use statistical techniques including longitudinal data analysis to assess the risk of developing heart disease and cancer. To address confounding we will use two complimentary methods to compare the cardiovascular risk factor profiles of psoriatic arthritis patients to the general population.Benefits:The proposed project will improve the understanding of health risks associated with psoriatic arthritis. These risks can be taken into account when caring for these patients. Specifically, lifestyle modification and targeted screening can improve the survival and quality of life of cardiovascular patients.In addition to the scientific goals, this project will facilitate the reintegration of the applicant into the European and Icelandic research community, while bringing new research techniques and knowledge to the host institution.
Original text from CORDIS.
Participants
- LANDSPITALI UNIVERSITY HOSPITAL · ReykjavikCoordinatorIceland
Links
Data: CORDIS, © European Union