INTERBONE · The interplay among bone cells, matrices and systems
FP7 — People (Marie Curie Actions)
- Duration
- 2012-04-01 → 2015-06-30
- EU contribution
- €233,100
- Participants
- 2
- Scheme
- MC-IRSES
Lines connect the coordinator with its partners.
Results in brief
The interplay among bone cells, matrices and systems
The skeleton does more than provide just a physical structure to the body. Bone cells play an important role in metabolism, in regulating health and protecting against disease. There is a highly complex web of interactions between bone cells, the other components of skeletal tissue, and cells and organs in other parts of the body. This is still poorly understood. INTERBONE, an interdisciplinary network for international exchange of scientists, has been supported by the European Union Framework 7 programme to study the central role of the skeleton in three areas of health. Work on energy metabolism in INTERBONE built on previous research findings that suggest a link between bone-derived signals, glucose metabolism and insulin sensitivity. The network also investigated the role of candidate secreted factors in the disruption of hematopoiesis in the development of leukemia. Research on fracture repair and tissue regeneration has addressed biomaterials interactions with cells, and stimulation of angiogenesis in fracture repair with biophysical approaches. The network, coordinated by Professor Anna Maria Teti at the University of L’Aquila, Italy, aimed to integrate research and training activities between 6 institutions: • University of L’Aquila, Italy • Erasmus Medical Centre, Netherlands • Universidade do Grande Rio, Brazil • Universidade Estadual Paulista, Brazil • Anna University, Chennai, India • Columbia University, USA The planned research collaboration was supported by a programme of staff exchanges, training and networking activities. The network planned regular meetings integrated with established international conferences in bone-related research, to support networking and dissemination, a workshop on tissue regeneration and angiogenesis, and a programme of webinars. INTERBONE aimed to make a contribution to the opening of the European Research Area to international cooperation, and interaction with three of Europe’s strategic global partners (USA, India and Brazil) in this emerging interdisciplinary area of research.
Data: CORDIS, © European Union
Project objective
It is now clear that there are multiple regulatory pathways that orchestrate the interplay between the skeleton and other organs to maintain the correct homeostasis of the body. INTERBONE is an interdisciplinary network for international exchange of scientists which will study the central role of the skeleton in three areas of health. INTERBONE will coordinate research and training activities between 5 institutions in Italy, Netherlands, Brazil, India and USA each with highly complementary and distinctive expertise. Work on energy metabolism will build on previous research findings that suggest a link between bone derived signals, glucose metabolism and insulin sensitivity. The network will also investigate the role of candidate secreted factors in the disruption of hematopoiesis in the development of leukemia. These activities will utilize new conditional knockout mouse models. Research on fracture repair and tissue regeneration will address biomaterials interactions with cells, and stimulation of angiogenesis in fracture repair with biophysical approaches. The planned research collaboration is supported by a programme of staff exchanges, training and networking activities. The network will involve regular meetings integrated with established international conferences in bone-related research, which will support networking and dissemination, a workshop on tissue regeneration and angiogenesis, and a programme of webinars. The staff to be exchanged will comprise 13 ESRs and 7 ERs who will benefit greatly from the transfer of knowledge and international experience. INTERBONE also makes a contribution to the opening of the European Research Area to international cooperation, and interaction with three of Europe’s strategic global partners in this emerging interdisciplinary area of research.
Original text from CORDIS.
Participants
- UNIVERSITA DEGLI STUDI DELL'AQUILA · L AQUILACoordinatorItaly
- ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM · RotterdamNetherlands
Links
Data: CORDIS, © European Union