Menu
MapConnectionsTopicsBulgariaThe Night (K-TRIO)Marie Skłodowska-CurieFor studentsFor teachersMethodologySurprise me
H2020Doctoral network2015–2019

ONCORNET · ONCOgenic Receptor Network of Excellence and Training

Horizon 2020 — Marie Skłodowska-Curie Actions

Duration
2015-01-01 → 2019-05-31
EU contribution
€3,893,983
Participants
16
Scheme
MSCA-ITN-ETN

Lines connect the coordinator with its partners.

Results in brief

ONCOgenic Receptor Network of Excellence and Training

Cancer is a leading health concern. There is a need to fully understand the fundamental processes underlying development of cancer. There is increasing evidence that G protein-coupled receptors (GPCRs) and their associated signalling cascades are involved in both cancer progression and metastasis. As oncogenic GPCRs are likely to be amenable to manipulation via drugs they are ideal therapeutic targets. In ONCORNET (Oncogenic GPCR Network of Excellence and Training) we target two oncogenic GPCRs; the chemokine receptors CXCR4 and CXCR7. These are highly expressed in a range of tumours and yet their role in cancer progression is not well understood. Within ONCORNET we focus on unravelling how CXCR4 and CXCR7 are or can be modulated (small molecules, pepducins, nanobodies) and investigate the role of CXCR4 and CXCR7 in (oncogenic) signalling. The key objective of this MSCA-ITN-ONCORNET initiative is to train 15 ESRs by offering an extensive multidisciplinary training programme to ensure that they can operate in today’s drug discovery programmes. This includes both research (e.g. drug discovery, proteomics, imaging, modelling) and transferable (e.g. entrepreneurship, writing, media training) skill sets – that is rarely offered at PhD level.

Data: CORDIS, © European Union

Project objective

Cancer is a leading health concern. There is a need to fully understand the fundamental processes underlying development of cancer. There is increasing evidence that G protein-coupled receptors (GPCRs) and their associated signalling cascades are involved in both cancer progression and metastasis. As oncogenic GPCRs are likely to be amenable to manipulation via drugs they are ideal therapeutic targets. In ONCORNET (Oncogenic Receptor Network of Excellence and Training) we propose to target two oncogenic GPCRs; the chemokine receptors CXCR4 and CXCR7. These are highly expressed in a range of tumours and yet their role in cancer progression is not well understood. We will focus on unravelling how CXCR4 and CXCR7 are or can be modulated (small molecules, pepducins, nanodies) and investigate the effects on oncogenic responses. This represents crucial knowledge that we currently do not have and yet may well provide potential leads for drug development and commercialisation. ONCORNET will bring together the leading research scientists and labs in Europe with an interest in GPCRs and 15 early stage researchers. We will employ all the latest multidisciplinary research technologies to understand the role of these GPCRs in cancer and develop CXCR4 and CXCR7 tools for diagnostic and therapeutic purposes. Importantly, developed approaches can be extrapolated to other oncogenic GPCRs. The ONCORNET consortium will offer an extensive multidisciplinary training programme to the ESRs to ensure that they can operate in today’s drug discovery programmes. This will include both research (e.g. drug discovery, proteomics, imaging, modelling) and transferable (e.g. entrepreneurship, writing, media training) skill sets –that is rarely offered at PhD level. We will train ESRs to develop the next generation of multidisciplinary scientists with skills that are highly demanded by many of today’s employers in drug development industries.

Original text from CORDIS.

Participants

  • STICHTING VU · AmsterdamCoordinatorNetherlands
  • 24 Media Labs · RotterdamNetherlands
  • ACTELION PHARMACEUTICALS LTD · AllschwilSwitzerland
  • ALMAC SCIENCES LIMITED · CRAIGAVONUnited Kingdom
  • ARGEN-X · ZwijnaardeBelgium
  • CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS · ParisFrance
  • CISBIO BIOASSAYS SAS · CODOLETFrance
  • EuroscreenSa · GosseliesBelgium
  • GRIFFIN DISCOVERIES BV · AMSTERDAMNetherlands
  • INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE · ParisFrance
  • JULIUS-MAXIMILIANS-UNIVERSITAT WURZBURG · WuerzburgGermany
  • MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV · MUNCHENGermany
  • THE UNIVERSITY OF NOTTINGHAM · NottinghamUnited Kingdom
  • UNIVERSIDAD AUTONOMA DE MADRID · MadridSpain
  • UNIVERSITY OF GLASGOW · GlasgowUnited Kingdom
  • VIVIA BIOSYSTMES S.L. · VALLADOLIDSpain

Links

Data: CORDIS, © European Union