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H2020Doctoral network2015–2019

MetaRNA · RNA-based technologies for single-cell metabolite analysis

Horizon 2020 — Marie Skłodowska-Curie Actions

Duration
2015-01-01 → 2019-06-30
EU contribution
€3,995,643
Participants
15
Scheme
MSCA-ITN-ETN

Lines connect the coordinator with its partners.

Results in brief

RNA-based technologies for single-cell metabolite analysis

Metabolism is the foundation of all living organisms. While cells in a population are often phenotypically different, most of our current analytical approaches still probe metabolism only at the population level. Because strong evidence exists that metabolic cell-to-cell heterogeneity has, for instance, disease relevance, researcher from MetaRNA overcame this severe analytical limitation through exploiting opportunities emerging from the RNA field. Such synergy potential between the metabolism and RNA research fields had until today not been exploited, because they were separated from each other in Europe and worldwide. Through consequently missing research training programs we thus lacked experts with combined knowledge in metabolism and RNA. The aim of the MetaRNA proposal was therefore to establish a European Training Network (ETN) that educates specialists for academia and industry - fully trained at the interface of these two fields - in the development and application of RNA-based sensors to investigate metabolism at the single-cell level, to apply these tools for novel biotechnological applications and to provide a framework for their future use in diagnostics and therapeutics. In MetaRNA, eight research groups from the metabolic and RNA fields and six partners from the private sector joined forces to create a platform of mobility and training to 15 early-stage researchers (ESRs), by means of customized research projects, exchange of knowhow among researchers and partners, attendance to specialized courses, workshops and conferences, as well as training in complementary skills.

Data: CORDIS, © European Union

Project objective

Metabolism is the foundation of all living organisms. While cells in a population are often phenotypically different, most of our current analytical approaches still probe metabolism only at the population level. Because strong evidence exists that metabolic cell-to-cell heterogeneity has, for instance, disease relevance, researcher from MetaRNA will overcome this severe analytical limitation through exploiting exciting opportunities emerging from the RNA field. Such synergy potential between the metabolism and RNA research fields has until today not been exploited, because they are separated from each other in Europe and worldwide. Through consequently missing research training programs we thus lack experts with combined knowledge in metabolism and RNA. The aim of the MetaRNA proposal is therefore to establish a European Training Network (ETN) that educates specialists for academia and industry - fully trained at the interface of these two fields - in the development and application of RNA-based sensors to investigate metabolism at the single-cell level, to apply these tools for novel biotechnological applications and to provide a framework for their future use in diagnostics and therapeutics. In MetaRNA, eight research groups from the metabolic and RNA fields and six partners from the private sector join forces to create a platform of mobility and training to 15 early-stage researchers (ESRs), by means of customized research projects, exchange of knowhow among researchers and partners, attendance to specialized courses, workshops and conferences, as well as training in complementary skills.

Original text from CORDIS.

Participants

  • RIJKSUNIVERSITEIT GRONINGEN · GroningenCoordinatorNetherlands
  • APTAIT GMBH · DIESSENGermany
  • BIOSYNTIA APS · HorsholmDenmark
  • CENTRE TECHNOLOGIQUE NOUVELLE-AQUITAINE COMPOSITES & MATERIAUX AVANCES · PessacFrance
  • DANMARKS TEKNISKE UNIVERSITET · Kongens LyngbyDenmark
  • DSM FOOD SPECIALTIES BV · DelftNetherlands
  • EVOLVA AG · ReinachSwitzerland
  • INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE · ParisFrance
  • KOBENHAVNS UNIVERSITET · KOBENHAVNDenmark
  • RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITAT BONN · BonnGermany
  • TECHNISCHE UNIVERSITAT DARMSTADT · DarmstadtGermany
  • THE FRANCIS CRICK INSTITUTE LIMITED · LondonUnited Kingdom
  • TPP Global Development Limited · EdinburghUnited Kingdom
  • UNITED KINGDOM RESEARCH AND INNOVATION · SWINDONUnited Kingdom
  • UNIVERSITY OF WARWICK · COVENTRYUnited Kingdom

Links

Data: CORDIS, © European Union