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H2020Doctoral network2015–2018

InCeM · Research Training Network on Integrated Component Cycling in Epithelial Cell Motility

Horizon 2020 — Marie Skłodowska-Curie Actions

Duration
2015-01-01 → 2018-12-31
EU contribution
€3,866,665
Participants
29
Scheme
MSCA-ITN-ETN

Lines connect the coordinator with its partners.

Results in brief

Research Training Network on Integrated Component Cycling in Epithelial Cell Motility

Cell migration (cell motility) is fundamental for the functioning of the human body. It is crucial for tissue formation and maintenance and is needed for wound healing. Cell migration is also essential for tumour invasion and metastasis during carcinogenesis. The underlying processes for cell migration are poorly understood at the mechanistic and regulatory level because of its complexity involving multiple cellular systems that are regulated through genetic, physical and biochemical signals. Yet, an integrated view is urgently needed for predicting and manipulating cell migration as a pivotal process in both health and disease. This knowledge is expected to open new avenues for the diagnosis of human diseases, their treatment and in regenerative medicine. To reach this goal, concerted interdisciplinary approaches were pursued involving experimentalists competent in different techniques and theoreticians with expertise in analysing multimodal experimental datasets and integrating them into multi-scale models. InCeM achieved this by bringing together these experts and training a new generation of researchers. InCeM developed and used novel devices for multimodal and multidimensional recording techniques of subcellular processes, extracted quantitative data from these recordings and measurements, and integrated large datasets into mechanistic mathematical models. These models were validated experimentally and can be used for tuning cell migration in vitro and in vivo to benefit tumour patients and the millions of patients suffering from chronic wounds.

Data: CORDIS, © European Union

Project objective

Cell migration (cell motility) is a fundamental biological process that is pivotal in (i) tissue formation and repair (health) and (ii) tissue invasion during carcinogenesis (disease). Understanding and controlling cell migration will have major clinical impact. Clarifying mechanisms driving cell motility has been challenging due to the complex underlying cellular mechanisms; these involve multiple components coordinated by structural, chemical and physical signals in terms of time and space. To accomplish breakthroughs in this field, researchers are needed who (i) master cutting-edge experimental techniques for monitoring the different cellular processes at high resolution and (ii) have competencies in theoretical science for integrating the resulting data sets into mechanistic mathematical models for predicting motile cell behaviour.The Research Training Network on Integrated Component Cycling in Epithelial Cell Motility (InCeM) aims to endow up-and-coming researchers with exactly these competencies. They will be able to develop and apply innovative devices for microscopic recording, image processing techniques, data analysis tools and modelling procedures for mechanistic understanding of cell migration. InCeM will focus on epithelial cells, since inducing motility in this cell type is clinically relevant for wound healing and cancer invasion. The ultimate goal is to control and manipulate cell migration for clinical applications. A dedicated multidisciplinary team of 11 beneficiaries from universities (4), research institutions (4) and industry (3), based in 5 European countries and Israel, together with 17 associated partners from the public and private sector, will train 15 Early Stage Researchers (ESRs) to use the relevant technologies and sciences and will offer business training to prepare them for successful careers in both academic and non-academic environments.

Original text from CORDIS.

Participants

  • UNIVERSITAETSKLINIKUM AACHEN · AachenCoordinatorGermany
  • ANDOR TECHNOLOGY LIMITED · BelfastUnited Kingdom
  • BAYER CROPSCIENCE AG · MonheimGermany
  • CARL ZEISS MICROSCOPY GMBH · JenaGermany
  • EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH · ZuerichSwitzerland
  • FORSCHUNGSZENTRUM JULICH GMBH · JULICHGermany
  • GRADIENTECH AB · UPPSALASweden
  • IBIDI GMBH · Planegg MartinsriedGermany
  • Isaac Newton Institute for Mathematical Sciences · CambridgeUnited Kingdom
  • Johann Radon Institute for Computational and Applied Mathematics · LinzAustria
  • KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW · AMSTERDAMNetherlands
  • LfB · MünsterGermany
  • MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV · MUNCHENGermany
  • NETHERLANDS TRANSLATIONAL RESEARCHCENTER BV · OSSNetherlands
  • PNO Life Sciences & Health B.V. · RijswijkNetherlands
  • RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITAT BONN · BonnGermany
  • SIRION BIOTECH GMBH · PLANEGG MARTINSRIEDGermany
  • SOFTWARE COMPETENCE CENTER HAGENBERG GMBH · HAGENBERGAustria
  • STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS · AmsterdamNetherlands
  • STRASCHEG CENTER FOR ENTREPRENEURSHIP GMBH · MUNCHENGermany
  • TEL AVIV UNIVERSITY · Tel AvivIsrael
  • THE UNIVERSITY OF MANITOBA · ManitobaCanada
  • THE UNIVERSITY OF SUSSEX · BrightonUnited Kingdom
  • TISSUEGNOSTICS GMBH · WienAustria
  • UNIVERSITAET DUISBURG-ESSEN · EssenGermany
  • UNIVERSITEIT UTRECHT · UtrechtNetherlands
  • UPPSALA UNIVERSITET · UppsalaSweden
  • Uppsala Innovation Centre · UppsalaSweden
  • WEIZMANN INSTITUTE OF SCIENCE · RehovotIsrael

Links

Data: CORDIS, © European Union