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H2020Doctoral network2015–2018

Chromatin3D · Chromatin Dynamics in Development and Disease

Horizon 2020 — Marie Skłodowska-Curie Actions

Duration
2015-01-01 → 2018-12-31
EU contribution
€3,782,583
Participants
17
Scheme
MSCA-ITN-ETN

Lines connect the coordinator with its partners.

Results in brief

Chromatin Dynamics in Development and Disease

Higher order organization of chromatin results in chromosomes, the main organizing factors in the nucleus that occupy discrete territories. Most nuclear processes occur or at least being initiated onto the chromosomes which makes them the main organizing factors in the nucleus. Several proteins that are involved in the replication of DNA, gene transcription and the processing of RNA are found enriched in discrete focal structures. An emerging question is how these structures assemble and are maintained in the absence of membranes and moreover what are the kinetics of stable binding and/or rapid exchange of their components. Overall objectives The overall objectives of Chromatin3D were: • To establish a European research platform of excellence in the field of chromatin dynamics and its impact on development and disease by integrating research from basic mechanisms to translational research applications. • To create a Network dedicated to the training of young researchers promoting their independent careers, their own scientific goals and future employment prospects. • To build durable links between the participating academic and non-academic organizations that will last beyond the duration of Chromatin3D. Importance for society

Data: CORDIS, © European Union

Project objective

The cell nucleus is organized and compartmentalized into a highly ordered structure that contains DNA, RNA, chromosomal and histone proteins which make up a structure called chromatin. The dynamics associated with these various components are responsible for regulating physiological processes and the overall stability of the genome. The destabilization of such regulatory mechanisms that act on the chromatin structure are implicated in pathologies such as cancer. Higher order organization of chromatin results in chromosomes which occupy discrete territories within the cell nucleus. Most nuclear processes occur or at least being initiated onto the chromosomes which makes them the main organizing factors in the nucleus. Several proteins that are involved in the replication of DNA, gene transcription and the processing of RNA are found enriched in discrete focal structures. An emerging question is how these structures assemble and are maintained in the absence of membranes and moreover what are the kinetics of stable binding and/or rapid exchange of their components. The dynamic assembly and modification of chromatin during developmental processes as well as the deregulation of such chromatin dynamics during the onset of disease lacks mechanistic insights at present. To address these questions we have put forward a multidisciplinary approach which involves molecular, cellular and systems level approaches by assembling a group of scientists from academia and industry with cross disciplinary expertise and capabilities.

Original text from CORDIS.

Participants

  • IDRYMA TECHNOLOGIAS KAI EREVNAS · IRAKLEIOCoordinatorGreece
  • AvantiCell Science Ltd · AyrUnited Kingdom
  • DIAGENODE · SeraingBelgium
  • EREVNITIKO KENTRO VIOIATRIKON EPISTIMON ALEXANDROS FLEMINGK · Vari-AthensGreece
  • EXIQON AS · VEDBAEKDenmark
  • FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA · GenovaItaly
  • FUNDACIO INSTITUT D'INVESTIGACIO BIOMEDICA DE BELLVITGE · L'Hospitalet De LlobregatSpain
  • ISTITUTO EUROPEO DI ONCOLOGIA SRL · MilanoItaly
  • KAROLINSKA INSTITUTET · STOCKHOLMSweden
  • LIFEGLIMMER GMBH · BERLINGermany
  • LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN · PlaneggGermany
  • MOSAIQUES DIAGNOSTICS GMBH · HannoverGermany
  • SB SCIENCE MANAGEMENT UG · BerlinGermany
  • THE UNIVERSITY OF EDINBURGH · EdinburghUnited Kingdom
  • UD-GENOMED MEDICAL GENOMIC TECHNOLOGIES KUTATAS-FEJLESZTESI ES SZOLGALTATO KFT · DEBRECENHungary
  • WEIZMANN INSTITUTE OF SCIENCE · RehovotIsrael
  • YELLOW RESEARCH · AmsterdamNetherlands

Links

Data: CORDIS, © European Union