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H2020Staff exchange2015–2019

HYMADE · Hybrid Drug Delivery Systems upon Mesoporous Materials, Self Assembled Therapeutics and Virosomes

Horizon 2020 — Marie Skłodowska-Curie Actions

Duration
2015-02-01 → 2019-01-31
EU contribution
€1,219,500
Participants
9
Scheme
MSCA-RISE

Lines connect the coordinator with its partners.

Results in brief

Hybrid Drug Delivery Systems upon Mesoporous Materials, Self Assembled Therapeutics and Virosomes

HYMADE focused on the development of capsules and engineered colloidal particles for drug delivery, combining mesoporous colloids, the layer-by-layer (LbL) assembly technique and virosomes. The capsules and particles developed during the project were investigated with a view toward their use in the treatment of cancer and inflammatory diseases such as rheumatoid arthritis and uveitis. The overarching aim of HYMADE was to employ a combination of hybrid materials to fabricate advanced drug delivery systems with controlled release and effective targeting to relevant biological entities, such as tumors. Our investigations also aimed to gain understanding of the self-assembly process of hybrid materials and insight into the transport properties of the drug delivery systems developed during the project. The biological fate of the drug delivery systems, along with their drug release, degradation and therapeutic efficiency were studied in vitro and in vivo with state of the art imaging techniques including confocal laser scanning microscopy and positron emission tomography. To achieve these goals, we relied on an international multidisciplinary team of scientists at the forefront of materials science, nanoparticle self-assembly, physics, chemistry, biophysics and molecular imaging. HYMADE was based on the exchange of Early Stage and Experienced Researchers between European and non-European academic institutions, and our team comprised investigators from Germany, Austria, France, Spain, the USA, Argentina and Armenia. HYMADE provided seconded researchers with unique and dynamic opportunities for professional, scientific, and personal development to enhance their career perspectives and generate highly skilled personnel at the interface of the materials and biomedical sciences.

Data: CORDIS, © European Union

Project objective

HYMADE focuses on the development of capsules and engineered colloidal particles for drug delivery combining mesoporous colloids, the Layer by Layer (LbL) technique and virosomes. The capsules and particles have potential applications in cancer and inflammatory diseases such as rheumatoid arthritis and uveitis. The project is based on the secondments of Early Stage Researchers and Experienced Researchers and networking and training activities between European and non European academic institutions. HYMADE aims to profit from the combination of hybrid materials to fabricate advanced drug delivery systems with controlled release and targeting efficiency of biological entities. The project also aims to gain understanding of the self assembly process of hybrid materials and the transport properties of the drug delivery systems.The biological fate, drug release, degradation and therapeutical efficiency of the drug delivery systems will be studied in vitro and in vivo with state of the art imaging techniques. To achieve these goals we have gathered an international multidisciplinary team with scientists at the forefront of Material Science, Self assembly, Physics, Chemistry, Biophysics and Imaging from Germany, Austria, France and Spain on the European side and from United States of America, Argentina and Armenia on the non European side.

Original text from CORDIS.

Participants

  • ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOMATERIALES- CIC biomaGUNE · San SebastianCoordinatorSpain
  • AIT AUSTRIAN INSTITUTE OF TECHNOLOGY GMBH · WienAustria
  • COMISION NACIONAL DE ENERGIA ATOMICA · BUENOS AIRESArgentina
  • CONSEJO NACIONAL DE INVESTIGACIONES CIENTIFICAS Y TECNICAS (CONICET) · Buenos AiresArgentina
  • REGENTS OF THE UNIVERSITY OF MICHIGAN · ANN ARBORUnited States
  • SORBONNE UNIVERSITE · ParisFrance
  • UNIVERSIDAD NACIONAL DE GENERAL SAN MARTIN · San Martin Buenos AiresArgentina
  • UNIVERSITAET LEIPZIG · LeipzigGermany
  • YEREVAN STATE UNIVERSITY FOUNDATION · YerevanArmenia

Links

Data: CORDIS, © European Union