FLUNOVELTY · Development of novel fluorinated reagents for preparation of drugs.
Horizon 2020 — Marie Skłodowska-Curie Actions
- Duration
- 2015-11-01 → 2016-10-31
- EU contribution
- €92,538
- Participants
- 1
- Scheme
- MSCA-IF
Lines connect the coordinator with its partners.
Results in brief
Development of novel fluorinated reagents for preparation of drugs.
The main objectives of Flunovelty project, performed at ESPCI (Paris, France) by Pavel Mykhailiuk with Prof. Janine Cossy, were to (a) develop the novel small fluorinated reagents; (b) to elaborate their novel reactions; and to (c) use this knowledge to discover novel synthetic approaches towards some known drugs. In fact, during this project we discovered the novel chemical reagent: difluoromethyldiazomethane (CF2HCHN2), and elaborated its chemistry. In particular, we used this reagent to synthesize diversely substituted difluoromethylpyrazoles: the core structures of known argochemicals: Bixafen (Bayer), Sedaxane (Syngenta), Fluxapyroxad (BASF) and Isopyrazam (Syngenta). In summaty, we have discovered a novel and cheaper approach to known agrochemicals. We believe that these methods will be finally implemented by agrochemical companies that will result in lowering the price of the corresponding pesticides, and eventually the food.
Data: CORDIS, © European Union
Project objective
Around 20% of all modern drugs are fluorinated organic molecules. During the recent years, however, pharmaceutical companies struggle to deliver novel drugs to the market, because of the lack of innovative practical reagents and reactions towards “drug-like” compounds. In this project, we will address this issue by discovering novel small fluorinating reagents - fluorinated diazoalkanes, - elaborate their practical reactions, and use this knowledge to develop alternative synthetic approaches to some known drugs (AS-136A, Celecoxib).
Original text from CORDIS.
Participants
- ECOLE SUPERIEURE DE PHYSIQUE ET DECHIMIE INDUSTRIELLES DE LA VILLE DEPARIS · ParisCoordinatorFrance
Links
- View on CORDIS
- DOI: 10.3030/654260
- https://arquivo.pt/wayback/20191212054126/https://www.lco.espci.fr/-Prof-Janine-Cossy
Data: CORDIS, © European Union