RvD3-RAVIS · Novel Resolvin D3: its Role and Actions in the Resolution of Aortic Valvular Inflammation and Stenosis
Horizon 2020 — Marie Skłodowska-Curie Actions
- Duration
- 2015-11-01 → 2019-04-03
- EU contribution
- €185,857
- Participants
- 1
- Scheme
- MSCA-IF-EF-RI
Lines connect the coordinator with its partners.
Results in brief
Novel Resolvin D3: its Role and Actions in the Resolution of Aortic Valvular Inflammation and Stenosis
Aortic valve stenosis is the most common cause of valvular heart disease and the third most common cardiovascular pathology after ischemic heart disease and hypertension, with the primary risk factor being increased age. It is a progressive disease driven by chronic inflammation that results in calcification and obstruction of the aortic valve with poor prognosis if left untreated. Most of the clinical trials have failed to stop the progression of aortic valve stenosis, and for that reason, the only available treatments are invasive surgical replacements and transcatheter interventions. Therefore new therapeutic strategies are needed but development of effective and targeted therapies that limit or prevent the progression of the diseases has been challenging and conceptual innovations are of uttermost importance. Hence the overall objectives of this project were to elucidate endogenous resolution programs in aortic valve stenosis and define the role and action of Resolvin D3 in aortic valve inflammation and calcification.
Data: CORDIS, © European Union
Project objective
Aortic valve stenosis is a progressive inflammatory disorder with poor prognosis if left untreated. Currently the only available treatment is invasive surgical replacement of the valve, therefore new therapeutic strategies are needed. Resolution of inflammation is an active process orchestrated by endogenous specialized proresolving lipid mediators (SPM). These include the resolvins that actively promote catabasis via their potent actions in anti-inflammation, proresolution, tissue regeneration and pain reduction. Recently the complete stereochemistry of resolvin D3 (RvD3) was established. Given its highly potent anti-inflammatory and proresolving actions in murine models and with human cells its role and actions in aortic stenosis (AS) remains to be uncovered. Thus, a goal of this proposal is to elucidate endogenous resolution programs in human aortic valves and define the role and action of RvD3 in AS and calcification. To address this the candidate will employ LC-MS-MS based LM metabololipidomics combined with clinically relevant parameters as well as biochemical and cellular assessments in samples from AS patients. In addition, RvD3 will be used as treatment in a novel preclinical model of murine AS. Implementation of the proposed project will maintain and enhance the candidate’s position at the forefront in the field of resolution biochemistry with advances into valvular pathology. Unraveling the role of RvD3 and resolution programs in aortic inflammation and resolution may enhance current understanding of the molecular mechanism contributing to chronic cardiovascular inflammation and introduce a novel concept for the pathology AS. Furthermore, it may lead to novel therapeutic strategies with a potential to slow or halt the hemodynamic progression of stenosis via turning on resolution programs.
Original text from CORDIS.
Participants
- KAROLINSKA INSTITUTET · STOCKHOLMCoordinatorSweden
Links
Data: CORDIS, © European Union