SUSAMIDE · Sustainable Synthesis of Amides
Horizon 2020 — Marie Skłodowska-Curie Actions
- Duration
- 2015-04-01 → 2017-03-31
- EU contribution
- €172,800
- Participants
- 1
- Scheme
- MSCA-IF-EF-ST
Lines connect the coordinator with its partners.
Results in brief
Sustainable Synthesis of Amides
This project aims to develop an unprecedented methodology for amide synthesis, allowing one to access “challenging” representatives. The synthesis of an amide group is paramount to organic chemistry. The amide function is present in many polymers, pharmaceuticals and agrochemicals. The classical, seemingly simple route for its synthesis is based on either acyl chlorides or the in situ activation of a carboxylic acid followed by reaction with amine. However, these methods are not always straightforward, and even simple amides cannot always be accessed efficiently by these means. The focus of this project is on the development of an unprecedented, broadly compatible synthetic method for challenging amides using hindered carboxylic acids and electron deficient amines which can also be sterically hindered. The power of newly developed synthetic methodology can best be demonstrated by its application to challenging targets of industrial importance. To this end, synthesis of the two Active Ingredients involving amide formation is demonstrated.
Data: CORDIS, © European Union
Project objective
Despite the ubiquity of the amide group, its synthesis is not always straightforward and the existing methods for amide formation score badly from the perspectives of economy and sustainability. This proposal aims to develop unprecedented methodology for amide synthesis, allowing one to access “challenging” representatives. Two routes are proposed to mitigate risk and to provide complementarity. The objective of the proposal is twofold: 1) to expand the available chemical space (allowing one to synthesize challenging amides previously considered inaccessible via library synthesis with existing methods) and 2) to substitute existing syntheses with better ones (delivering higher yields without using toxic reagents and minimizing waste). Achieving these two objectives will have an impact on the discovery of new molecular entities and the improvement of production processes in the fine chemicals sector. The power of the new methodology will be demonstrated on the synthesis of selected real-life examples, APIs (Active Pharmaceutical Ingredients).
Original text from CORDIS.
Participants
- UNIVERSITEIT ANTWERPEN · AntwerpenCoordinatorBelgium
Links
Data: CORDIS, © European Union