ORSETOSY · Organocatalysis at the service of total synthesis: Madangamine alkaloids
Horizon 2020 — Marie Skłodowska-Curie Actions
- Duration
- 2015-04-27 → 2017-04-26
- EU contribution
- €183,455
- Participants
- 1
- Scheme
- MSCA-IF-EF-ST
Lines connect the coordinator with its partners.
Results in brief
Organocatalysis at the service of total synthesis: Madangamine alkaloids
During the course of this project, we have developed a new synthetic methodology toward the core of madangamine alkaloids, a family of six complex alkaloids isolated from a marine sponge, which have already shown cytotoxicity against different cancer cell lines. However, some of these compounds have not been studied yet due to the difficulty in isolation from the natural organisms. Therefore, it is highly desirable to develop a new methodology to prepare these compounds in a scalable fashion and in high yield. At the same time, the development of new reactions towards the preparation of fully substituted highly decorated amines is desirable because it can be applied as a new tool in the arsenal of reactions used in total synthesis.
Data: CORDIS, © European Union
Project objective
This project will develop a new, highly enantioselective, state-of-the-art synthetic route to the madangamine alkaloids B, C and E based on a novel organocatalytic desymmetrization reaction as a key step, which will allow the rapid and efficient construction of the BC rings ready for subsequent advancement to the majority of the family members. Evaluation of the anti-cancer biological activity of the different madangamines and late stage intermediates will be carried out. This Fellowship project combines total synthesis, new asymmetric methodology development via organocatalysis and biological evaluation. It has been designed to augment and complement the research and transferable skills sets of the Marie Curie fellow, and will greatly enhance his career prospects accordingly. Through the training and the research results arising, the Fellowship will be beneficial to the fellow, the host institution and European science.
Original text from CORDIS.
Participants
- THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD · OxfordCoordinatorUnited Kingdom
Links
- View on CORDIS
- DOI: 10.3030/660125
- http://dixon.chem.ox.ac.uk/
- https://arquivo.pt/wayback/20190325054748/http://dixon.chem.ox.ac.uk/
Data: CORDIS, © European Union