MemoMCI · Targeting reconsolidation to strengthen memories in individuals with Mild Cognitive Impairment
Horizon 2020 — Marie Skłodowska-Curie Actions
- Duration
- 2016-09-01 → 2018-08-31
- EU contribution
- €168,277
- Participants
- 1
- Scheme
- MSCA-IF-EF-RI
Lines connect the coordinator with its partners.
Results in brief
Targeting reconsolidation to strengthen memories in individuals with Mild Cognitive Impairment
Episodic memory displays the largest degree of age-related decline. This condition is accelerated in amnestic mild cognitive impairment (aMCI), which is often the precursor for emerging Alzheimer’s disease (AD). Since AD produces tremendous chronic burdens on individuals, families and health care systems around the world, the development of effective interventions to prevent or delay AD is an urgent priority. Noninvasive brain stimulation with transcranial direct current (tDCS) has demonstrated efficacy in enhancing long-term memory in healthy human subjects. In addition, reactivation of consolidated memories triggers reconsolidation, a time-limited period during which consolidated memories can be modified (e.g. strengthened). Recent reconsolidation studies in older adults have shown that tDCS over the prefrontal cortex (PFC) significantly strengthened consolidated verbal episodic memories. The aim of this study was twofold: 1) To determine whether active relative to sham/placebo tDCS applied over the PFC after a memory reactivation would enhance episodic memory performance in older adults with aMCI; 2) To identify aMCI individuals who can benefit the most from this tDCS intervention based on gray matter and white matter integrity assessed using magnetic resonance imaging (MRI), or presence of specific genetic polymorphisms (BDNF, SNAP-25) associated to memory. To accomplish his career goal of becoming an independent researcher, the fellow's training objectives were: 1) To develop a strong knowledge in neuropsychological evaluations, mechanisms of rehabilitation and recovery, and cognitive rehabilitation interventions tailored to meet individuals' specific needs using an interdisciplinary approach; 2) To develop additional technical skills in MRI; 3) To familiarize himself with molecular genotyping; 4) To enhance his teaching experience.
Data: CORDIS, © European Union
Project objective
Memory for unique personal experiences (episodic memory) is critical to daily life functioning. This form of long-term memory also displays the largest degree of age-related decline. This condition is accelerated in amnestic mild cognitive impairment (aMCI), which is often the precursor for emerging Alzheimer’s disease (AD). Since AD produces tremendous chronic burdens on individuals, families and health care systems around the world, the development of effective therapeutic interventions to prevent or delay AD is an urgent international priority. Noninvasive brain stimulation with transcranial direct current (tDCS) has demonstrated efficacy in enhancing long-term memory in healthy human subjects. In addition, reactivation of consolidated memories triggers reconsolidation, a time-limited period during which existing memories can be strengthened. Recent reconsolidation studies in healthy young and older adults have shown that noninvasive stimulation of the prefrontal cortex (PFC) significantly strengthens existing verbal episodic memories. In this double-blind, placebo-controlled study, I test the hypothesis that facilitatory tDCS over the PFC will strengthen existing verbal memories through reconsolidation in individuals with aMCI. In addition, I will determine specific biomarkers to help identify individuals who benefit the most from this tDCS intervention based on variations in brain structure or presence of genetic polymorphisms. These data will provide preliminary information that is crucial for the design of multicentre, longitudinal, placebo-controlled clinical trials, which are needed to validate this novel experimental intervention. This fellowship will provide me with the training in neurorehabilitation, the possibility to learn new skills (neuroimaging and genetics) through secondments, and the opportunity to build the interdisciplinary collaborations I need to become an independent and successful scientist in the field of neuroplasticity.
Original text from CORDIS.
Participants
- CASA DI CURA PRIVATA DEL POLICLINICO SPA · MILANOCoordinatorItaly
Links
- View on CORDIS
- DOI: 10.3030/658496
- http://www.ccppdezza.it/en/research-area/memomci-european-project-msca-h-2020/
Data: CORDIS, © European Union