FORECAST · Fluorescence lifetime optical biopsy system
Horizon 2020 — Marie Skłodowska-Curie Actions
- Duration
- 2017-01-01 → 2018-12-31
- EU contribution
- €195,455
- Participants
- 1
- Scheme
- MSCA-IF
Lines connect the coordinator with its partners.
Results in brief
Fluorescence lifetime optical biopsy system
The “Fluorescence lifetime optical biopsy system” (FORECAST) Fellowship has successfully reached its ultimate goal of training a talented researcher, Dr. Evgeny Zherebtsov, through a research project in the area of developing laser-based photonic devices for biomedical research and clinical diagnostics. The research in the area of optical biopsy systems, where fluorescence spectroscopy is one of the key approaches, is rapidly expanding due to its safety, relative cheapness and efficiency. The ability to recognize the suspect tissue in a second without interruption of the procedure dramatically increases the effectiveness of the endoscopic surgical removal of the cancerous tumours. The project focused on the development of novel tools for the in vivo real-time assessment of the respiratory chain activity (NADH/FAD ratio) and mitochondrial dysfunction in tissues. This is achieved by means of both laser fluorescence spectra and lifetime fluorescence data analysis supplemented with additional optical measurements (laser Doppler flowmetry, tissue reflectance spectroscopy) in order to correct the impact of affecting factors (changes in blood perfusion, blood volume, blood oxygenation). The FORECAST project sets the following list of key objectives (RO): broadening of the Fellow’s expertise in frequency domain lifetime fluorescence spectroscopy with a focus on medical applications; development of novel theoretical models for the registering fluorescence parameters in living epithelium tissue; design an advanced technique for registration of the fluorescence lifetime fluorescence intensity in a wide spectral range simultaneously with LDF and tissue blood oximetry measurements; expansion of experience in the field of the assessment of mitochondrial dysfunction according to the fluorescence parameters in tissues; expansion of experience in the field of medical monitoring for non-invasive fluorescence diagnosis of epithelium cancers.
Data: CORDIS, © European Union
Project objective
The ultimate goal of this Fellowship is to train a talented researcher through a research project focused on the development of novel tools for the in vivo real-time assessment of the respiratory chain activity (NADH/FAD ratio) and mitochondrial dysfunction in tissues. This will be achieved by means of both laser fluorescence spectra and lifetime fluorescence data analysis, supplemented with additional optical measurements (laser Doppler flowmetry, tissue reflectance spectroscopy) in order to correct the impact of affecting factors (changes in blood perfusion, blood volume, blood oxygenation). The Fellow – Dr. Evgeny Zherebtsov – will be trained in biomedical optics, a fast growing field of science and medical application.He will receive access to a unique training experience at the host – Aston Institute of Photonics Technologies (AIPT), Aston University (Prof. E. Rafailov), and at academic and industrial secondment partners: University College London (Prof. Andrey Abramov), University of Bari, Italy (Prof. Annamaria De Luca), Axxam S.p.A., Italy (Dr Jean-Francois Rolland). The FORECAST outputs will be relevant to the EU life sciences sector by offering new cost-efficient technologies for real-time in vivo screening studies of metabolic activity in application of testing of new chemicals for efficacy and safety in small animals and test tubes during drug discovery and epithelium cancer diagnostics. The products transformed from the FORECAST outputs will contribute to the enhancement of EU scientific excellence. The project brings together a talented young Fellow with a strong biomedical science and engineering background, and an internationally growing group of researchers at Aston University with expertise in the area of developing laser-based photonic devices for biomedical research and clinical diagnostics. The Fellow will be further supported by medical expert co-hosts who will help train the Fellow in key skills and support the translation process.
Original text from CORDIS.
Participants
- ASTON UNIVERSITY · BirminghamCoordinatorUnited Kingdom
Links
- View on CORDIS
- DOI: 10.3030/703145
- http://www.researchgate.net/project/Fluorescence-lifetime-optical-biopsy-system
Data: CORDIS, © European Union