Menu
MapConnectionsTopicsBulgariaThe Night (K-TRIO)Marie Skłodowska-CurieFor studentsFor teachersMethodologySurprise me
H2020Individual fellowship2016–2018

PlaEndo · The Remote Control of Maternal Metabolism by the Placenta

Horizon 2020 — Marie Skłodowska-Curie Actions

Duration
2016-09-01 → 2018-09-25
EU contribution
€195,455
Participants
1
Scheme
MSCA-IF-EF-ST

Lines connect the coordinator with its partners.

Results in brief

The Remote Control of Maternal Metabolism by the Placenta

Pregnancy is characterised by profound changes in maternal physiology. For instance, there are changes in the metabolic, cardiovascular, immune and renal systems of the mother which enable her to support fetal nutrient supply and growth. These changes are signalled in part by the production of protein hormones by the placenta (Napso et al., 2018). Failures in maternal adaptation and placental function lead to pregnancy complications such as abnormal birth weight and gestational diabetes which have immediate and lifelong health consequences for mother and child. However, we lack information on the identity of hormones secreted by the placenta that mediate the changes in maternal physiology. This study aimed to unbiasedly characterise the secretory output of cultured placental cells and there impact on maternal physiology and fetal development.

Data: CORDIS, © European Union

Project objective

During pregnancy many physiological changes occur in the mother that are designed to support fetal growth. These include changes in the cardiovascular, pulmonary, immune and metabolic systems. In particular, the mother becomes less reactive to insulin, leading to increased glucose availability to the fetus in late pregnancy. These adaptations are thought to be signaled, in part by changes in placental hormone production. Whilst studies have shown that the placenta has the capacity to produce different hormones, their specific role in adapting maternal metabolism during pregnancy relies principally on association studies. Moreover, there are likely to be more protein mediators secreted by the placenta with systemic actions in the mother. Failure to adjust the mother's body to the pregnant state may result in pregnancy complications, including abnormal birth weight and maternal diabetes, which can further lead to a range of medical complications for the mother and baby. The overall goal of this study will be to identify the nature and wider biological significance of placental endocrine function in adapting the mother's body during pregnancy to support fetal growth, with a focus on maternal metabolism. This work will primarily use the mouse as an experimental model as the placental signaling/secreting cells are conveniently organized into a distinct region and are under unique genetic control. Therefore placental signaling cells can be isolated, cultured and genetically-modified independent of other cells in the mouse placenta. The secreted placental candidates will be identified using the latest sequencing technologies, and their metabolic effects will be tested on cell lines and in the whole organism using unique genetic tools available at the University of Cambridge. Knowledge gained from this study will be the first step in the development of targeted interventions for optimizing fetal growth and preventing pregnancy complications.

Original text from CORDIS.

Participants

  • THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE · CAMBRIDGECoordinatorUnited Kingdom

Links

Data: CORDIS, © European Union