H2020Individual fellowship2016–2018

FLAMENCO · FLAgellated MicroswimmErs’ locomotioN in Confined flOws

Horizon 2020 — Marie Skłodowska-Curie Actions

Duration
2016-08-01 → 2018-07-31
EU contribution
€183,455
Participants
1
Scheme
MSCA-IF-EF-ST

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Results in brief

FLAgellated MicroswimmErs’ locomotioN in Confined flOws

The objective of this project is to study swimming at the micrometer scale. We are interested in addressing the strategies adopted by microorganisms and cells to achieve propulsion in a fluid environment. Cell motility is critical to accomplish essential surviving tasks, like feeding and evading predators, or specialized functions, as fertilizing the egg cell in the case of spermatozoa. While we can easily acknowledge why motility is important, it is more difficult to understand how cells swim. Swimming at the micro-scale is indeed counterintuitive and challenges the physical intuitions we build living in the macroscopic world. Our focus is on improving the mathematical and numerical modeling of locomotion at scales that range between a few to hundreds of micrometers to provide computational tools with both a descriptive and predictive power. We are in fact guided by the ambition of improving the fundamental understanding of this phenomenon and using this knowledge to inspire biomimetic robot and the design of microfluidic devices to manipulate and sort motile cells. An improved modeling capability for the motion of microswimmers has the potential of impacting several fields: microswimmers play a crucial role for a wide range of biological, ecological, and industrial processes, e.g. the fertilization of mammalian ova, production of algal biofuels, and the degradation of particulate organic matter by bacteria. As an example, an important and largely unsolved case is biofouling where immersed surfaces become covered by microorganisms, which affect the surface performance and can even lead to its failure. The main objectives of this project were the training of the researcher in computational modeling of micro-swimming and the development of numerical and computational models for simulating swimming at the micro-scale and study confined and collective motion.

Data: CORDIS, © European Union

Project objective

The ultimate goal of this Fellowship, entitled “FLAgellated MicroswimmErs’ locomotioN in Confined flOws” (FLAMENCO) is to train a talented researcher in computational modelling of micro-swimming. A variety of interdisciplinary training activities are planned with the purpose of transferring the cutting-edge knowledge in theoretical, computational and experimental microswimmer dynamics. The specialist training will be provided by Queen Mary University (Engineering Department), which, through this action, will establish a long-term collaboration network with the University of Warwick (Physics Department), the International School for Advanced Studies (SISSA) in Trieste, and the University of Padova (Department of Medicine). The interdisciplinarity of the institutes involved will allow the experienced researcher (ER) to appreciate the potential of the acquired knowledge for tackling problems relevant to field as diverse as engineering, biology, reproductive medicine and medical diagnostic. The innovation of this program consists in aiming at the quantitative understanding and mathematical modelling of phenomena that can mainly be described qualitatively at present. The outcomes will potentially provide the tools and body of knowledge for controlling and manipulating microswimmers near the solid surfaces. The intermediate objectives (deliverables) of this research project are (1) the derivation of a validated micro-swimmer/ surface interaction model, (2) a validated swimming swarm model at high-fidelity and ‘low-order’ level, (3) recommendations for separating swimming spermatozoa based on their motility.

Original text from CORDIS.

Participants

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Data: CORDIS, © European Union