RESOLVE · antibiotic RESistance and mObile genetic eLements dissemination in enVironmEntal conditions
Horizon 2020 — Marie Skłodowska-Curie Actions
- Duration
- 2016-08-01 → 2018-07-31
- EU contribution
- €173,076
- Participants
- 1
- Scheme
- MSCA-IF-EF-ST
Lines connect the coordinator with its partners.
Results in brief
antibiotic RESistance and mObile genetic eLements dissemination in enVironmEntal conditions
Antimicrobial resistance (AMR) is one of the most concerning public health threads of our times. Horizontal gene transfer (HGT) via mobile genetic elements is a key element for the acquisition/dissemination of AMR genes by bacteria. The environment constitutes a large reservoir of AMR genes and there is evidence that at environmentally relevant concentrations, some antibiotics may mediate HGT. Biofilms, which are the principal mode of life of bacteria in the environment, have been proposed to be structures promoting gene transfer. However, the demonstration of the actual transfer, the dynamics and regulation of such MGEs in a complex environmental matrix, is yet experimentally challenging. This left important questions unanswered, such as, how and when transfer and dissemination of ARGs actually occur in nature. The overall aim of this project was to investigate whether wastewaters, as an environmental parameter, are hot-spots for horizontal gene transfer.
Data: CORDIS, © European Union
Project objective
Multidrug-resistant bacteria are spreading worldwide and present a serious public health issue. Bacterial resistance has to be addressed with a global approach connecting human health with animals and the environment. Mobile genetic elements (MGEs) such as bacterial plasmids, transposons or cassettes of integrons, as frequent carriers of antibiotic resistance genes (ARGs), play an important role in the global spread of ARGs among bacterial communities. My research aims to understand how environmental parameters could modulate the dynamics of MGEs involved in ARG dissemination and contribute to the global burden of antibiotic resistance. For this aim, I will use a global approach that merges medical and molecular microbiology, microbiota studies and genomic studies (employing next generation sequencing techniques). Single monospecies-biofilms as well as natural biofilms grown from wastewaters will be used as models of investigation. The proposed research will profoundly improve my knowledge in molecular and medical microbiology techniques to study MGEs associated with antibiotic resistance. This project will be pivotal for my personal development to become an independent researcher and will provide me with the unique opportunity to work with experts in the field of MGEs, antibiotic resistance and the environment. I will be exposed to novel ideas and input from renowned researchers belonging to scientific disciplines unrelated to my background that will have a strong impact on my personal and scientific development. Furthermore, I aim to establish a series of lectures and seminars for the general (research) community to further increase awareness of the importance and relevance of the global fight against antibiotic resistance.
Original text from CORDIS.
Participants
- UNIVERSITE DE LIMOGES · LimogesCoordinatorFrance
Links
Data: CORDIS, © European Union