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H2020Individual fellowship2016–2018

BEND · Bendable Bioplatform for Electrically stimulated Neuronal Differentiation

Horizon 2020 — Marie Skłodowska-Curie Actions

Duration
2016-08-15 → 2018-08-14
EU contribution
€195,455
Participants
1
Scheme
MSCA-IF-EF-ST

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Results in brief

Bendable Bioplatform for Electrically stimulated Neuronal Differentiation

Self-health monitoring and Point of care diagnosis (PoC) are focus areas for wearable/implantable devices as they allow monitoring of analytes from closer vicinity of a patient. However, the state-of-the-art PoC devices employ chemically or mechanically thinned compatible metal wafer or synthetic polymer which lacks compatibility enough to be conformable and even develop allergic or inflammatory responses to the patient. So, compatibility of state-of-the-art implantable/wearable devices remains as major challenge in self-health monitoring comfortably. The use of biopolymer-based electronics platform could be a major focus in solving this critical issue. This Marie Curie Individual fellowship (Project ID: BEND 704807) proposed a bendable bioplatform for holding the electronic circuitry for the development of wearable/implantable electronic devices. Herein, a chitosan biopolymer based biocompatible platform with tunable degradability was developed as bioresorbable patch. The chitosan suspension was drop-casted on a carrier wafer and allowed overnight for air drying to yield chitosan substrate. Then the substrate was chemically cross-linked with Glutaraldehyde for attaining stability in aqueous medium. Biocompatibility of the fabricated platform was evaluated with in vitro human dermal cell adhesion and proliferation. Interdigitated Au electrode established Chi substrate was employed for electrically stimulated neurite differentiation. The Chi based electrode was also employed for cell health monitoring. With these results, we demonstrated that the developed bioplatform could be useful for holding the wearable/implantable devices without any compatibility issues.

Data: CORDIS, © European Union

Project objective

Summary of Marie Curie Proposal for H2020-MSCA-IF-2015 “Bendable Bioplatform for Electrically stimulated Neuronal Differentiation”With western countries aging faster, the neurodegenerative diseases like Parkinson’s, Alzheimer’s, Huntington’s etc. pose serious threat to quality of life, especially for people over 65 years[1]. In Europe, number of people suffering with dementia, which results from neuronal degeneration, is on the rise it is expected to be double in the next 20 Years[2]. The neuronal degeneration is irreversible[3] and currently the cell therapy for regeneration of neuron network is the only option to compensate such a loss. Recently, the induced pluripotent stem cell (iPSC) derived NSC therapy has come up as an excellent opportunity in treating of neuro degenerative diseases. However, proliferation and differentiation of iPS cell population in neuronal replacement therapies poses many technical challenges such as targeted neurite differentiation to compensate desired loss with controlled differentiation[4]. Traditionally, the neuronal differentiation of iPSC is performed using several transcriptional and growth factors, which are complex, expensive and non-scalable processes[5]. For this reason, the research for a simple, robust and scalable method for generating large number of mature, differentiated neuronal cell deserves top priority. In addition, an accurate on/off system for scalable proliferation and neuronal differentiation is pivotal for the development of implantable bioelectronics circuit suitable for in vivo application. It is believed that the electrical stimulus controlled neuronal differentiation of stem cells on a soft, bendable electro conductive substrate can be suitable for bioelectronics application and also for compensating neuronal loss in the degenerative disease or injuries. This project is an ambitious endeavour in this direction. A bendable bioplatform will be developed for electrically stimulated neural differentiation t

Original text from CORDIS.

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Data: CORDIS, © European Union