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H2020Doctoral network2017–2021

TransPot · Translational Research Network in Prostate Cancer

Horizon 2020 — Marie Skłodowska-Curie Actions

Duration
2017-01-01 → 2021-04-30
EU contribution
€2,629,316
Participants
17
Scheme
MSCA-ITN-ETN

Lines connect the coordinator with its partners.

Results in brief

Translational Research Network in Prostate Cancer

TransPot (The Translational Research Network for Prostate Cancer) is an innovative programme designed to tackle incurable prostate cancer (PC). Prostate cancer is a global health concern and is an important cause of premature cancer related deaths in men. Treatment resistance remains a challenge and patients with cancer relapse following previous hormone treatment tend not to respond well to treatment. Therefore there is an urgent need to find better treatment for patients who are resistant to current therapies. This will allow improved outcome among prostate cancer sufferers, hopefully with extended survival and better quality of life, and will have direct societal and economic impacts. The purpose of the training network was to provide an excellent opportunity for a group of young researchers to receive training in becoming translational scientists in the field of cancer biology, therapeutics development and biomarker discovery. The key objectives of the project were: (1) to gain better understanding of treatment resistant prostate cancer, (2) to find new treatment strategies to overcome treatment resistance, (3) to discover new tests or methods to predict cancer response to treatment and the likelihood of cancer progressing after treatment, (4) to develop a holistic tool for ‘tailor-made’ treatment for individual patients with treatment resistant prostate cancer.

Data: CORDIS, © European Union

Project objective

The Translational Research Network for Prostate Cancer (TransPot) program adopts an innovative, multidisciplinary approach, providing highly sought-after, effective solutions for incurable prostate cancer (PC).The TransPot scientific objective is to obtain an unmatched depth of molecular, mechanistic and informatics systems-level disease understanding in order to improve the prognosis and treatment of lethal PC, aimed to (i) provide important insights into molecular mechanisms driving treatment resistant PC including castrate-resistant PC (CRPC), (ii) identify novel therapeutic targets, (iii) develop and validate predictive models for disease progression, prognosis and responsiveness to current and novel (co-)treatment options, and (iv) provide superior, clinically relevant tools and biomarker signatures for personalising and optimising CRPC therapy. Our research program is built on network-wide, state-of-the-art cancer biology-based mechanistic research integrated with a systems medicine approach: 1. Cancer biology-based mechanistic research incorporating a comprehensive range of model systems incorporating unique, pre-clinical and clinical resources and distinct phenotypic high content screen platforms. 2. A systems medicine approach with mathematical modelling to develop novel predictive/prognostic tools. 3. Centres of excellence in surgery, oncology and clinical trials, comprising clinical infrastructure and essential resources whereby candidate therapeutic targets and predictive/prognostic tools can be comprehensively evaluated, including accessing bio-repository resources. We will train young scientists to apply multiple ‘omics’ technologies and approaches in model systems and systems biology to answer important clinically-relevant questions. Advances achieved will facilitate personalized targeted-medicine in treating lethal PC, and will impact beyond the scientific community by improving the well-being of advanced PC patients.

Original text from CORDIS.

Participants

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Data: CORDIS, © European Union