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H2020Doctoral network2016–2020

CORE · Continuous Resolution and Deracemization of Chiral Compounds by Crystallization

Horizon 2020 — Marie Skłodowska-Curie Actions

Duration
2016-10-01 → 2020-12-31
EU contribution
€3,926,004
Participants
15
Scheme
MSCA-ITN-ETN

Lines connect the coordinator with its partners.

Results in brief

Continuous Resolution and Deracemization of Chiral Compounds by Crystallization

The CORE Network is a Marie Skłodowska-Curie European Training Network on Continuous Resolution and Deracemization of Chiral Compounds by Crystallization that ran from October 2016 to December 2020. The CORE Network brought together 14 partners from 6 European countries resulting in an unparalleled combination of chirality, synthesis and crystallization training and research covering the areas of Chemical Engineering, Chemistry and Applied Physics. Most pharmaceutical and specialty compounds are chiral. Chiral molecules occur in left-handed and right-handed configurations that can be considered as mirror images (enantiomers), and that, like hands, cannot be superimposed onto each other. Despite their similarity, the biological activity of left- and right-handed molecules can be completely different because of the homochirality of nature. This is exemplified by the drug Thalidomide (Softenon) that was developed by the pharmaceutical company Chemie Grünenthal some 60 years ago: one of the enantiomers prevents morning sickness during pregnancy whereas the other enantiomer influences embryonic development and resulted in children with malformed limbs. Since most future pharmaceuticals will be chiral, chiral resolution, the process to obtain enantiopure molecules, is of paramount importance. The network proposed a CORE Industrial Toolbox that enables the design of Crystallization-based Continuous Chiral Resolution and Deracemization processes resulting in high enantiopurity, high productivity and high yield for newly developed high-value chiral products such as future pharmaceuticals. This CORE Industrial Toolbox was developed by the 15 Early Stage Researchers (ESRs) while they were trained in the network on their knowledge, personal, organizational and impact skills to become the future outstanding employees of the European pharmaceutical industry.

Data: CORDIS, © European Union

Project objective

Industries are in need of highly skilled academically trained experts and powerful sets of tools enabling the design, control & prediction of optimized & efficient production process of future high-value products such as chiral pharmaceuticals. The CORE Network will in parallel train 15 ESRs and develop tools, approaches and methods within the area of Continuous Resolution (CORE), the process to obtain enantiopure molecules of chiral compounds.The training objective of the CORE network is to deliver a CORE skills toolbox of knowledge, personal, organizational and impact skills to a core of multi-disciplinary scientists and engineers in the interdisciplinary and cross-sectional field of Continuous Resolution. Each ESR obtains dedicated training through their research project, network events, a webinar course, management involvement and an academic & industrial secondment.The research objective of the CORE Network is to jointly construct a CORE Industrial Toolbox on Continuous Resolution that provides next generation tools, approaches and methods to industry for the development continuous resolution processes. The strongly involved industrial partners will ensure that the CORE Industrial Toolbox fulfils their requirements in the skills gap areas Towards Continuous, Hybrid Resolution and Enabling Resolution. CORE brings together 8 academic and 7 industrial partners resulting in an unparalleled combination of chirality, synthesis and crystallization training and research covering the areas of Chemical Engineering, Chemistry and Applied Physics.

Original text from CORDIS.

Participants

  • UNIVERSITY OF STRATHCLYDE · GlasgowCoordinatorUnited Kingdom
  • CHEMCONNECTION BV · OSSNetherlands
  • EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH · ZuerichSwitzerland
  • FRIEDRICH-ALEXANDER-UNIVERSITAET ERLANGEN-NUERNBERG · ErlangenGermany
  • MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV · MUNCHENGermany
  • MERCK KOMMANDITGESELLSCHAFT AUF AKTIEN · DarmstadtGermany
  • OTTO-VON-GUERICKE-UNIVERSITAET MAGDEBURG · MagdeburgGermany
  • PCAS · EcullyFrance
  • PURAC BIOCHEM BV · GORINCHEMNetherlands
  • SIEMENS PROCESS SYSTEMS ENGINEERING LIMITED · LONDONUnited Kingdom
  • STICHTING RADBOUD UNIVERSITEIT · NijmegenNetherlands
  • SYNCOM BV · GroningenNetherlands
  • THE UNIVERSITY OF MANCHESTER · ManchesterUnited Kingdom
  • TeraCrysta SRL · Cluj-NapocaRomania
  • UNIVERSITE DE ROUEN NORMANDIE · MONT SAINT AIGNAN CEDEXFrance

Links

Data: CORDIS, © European Union