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H2020Doctoral network2017–2020

DNAREPAIRMAN · Regulated Assembly of Molecular Machines for DNA REPAIR: a Molecular Analysis training Network

Horizon 2020 — Marie Skłodowska-Curie Actions

Duration
2017-01-01 → 2020-12-31
EU contribution
€3,079,270
Participants
13
Scheme
MSCA-ITN-ETN

Lines connect the coordinator with its partners.

Results in brief

Regulated Assembly of Molecular Machines for DNA REPAIR: a Molecular Analysis training Network

The DNARepairMan training network (Regulated Assembly of Molecular Machines for DNA Repair: a Molecular Analysis Training Network) consists of 12 European participants coming from academia, industry and the creative sector. The network aims to train 12 young scientists in cutting edge biophysical research methodology to address central questions in biology with relevance for human health. This is motivated by the understanding that the future development of novel targeted therapies and antimicrobials will rely precisely on understanding the molecular and mechanistic details underlying disease. Our focus on the process of DNA repair arises from its essential role in maintaining genome stability. In this process multiple proteins collaborate as large molecular machines to detect and repair very rare errors that occur in DNA. These evolutionarily-conserved processes are of fundamental importance, and there is an increasing awareness that targeting of DNA repair pathways could also be useful in the development of personalized anti-cancer therapies and new antimicrobials. This Training Network uniquely brings together biologists, chemists, and physicists around a common research question: What are the mechanistic details that underlie the molecular organization of DNA repair? The objectives of DNARepairMan are - To unravel the mechanistic details of two DNA repair pathways and how they interact with DNA replication and transcription - To develop new reagents, assays, technology and software to analyze fundamental chemical and physical principles - collaborate with an Art Academy to explore new ways and means to visualize research projects and explain the importance of fundamental research to society.

Data: CORDIS, © European Union

Project objective

The European Training Network DNAREPAIRMAN aims to train a new generation of innovative young scientists in cutting edge biophysical research methodology to address central questions in biology concerning the mode of action of critical molecular machines with relevance for human health. The Network consists of a highly collaborative consortium consisting of 12 participants coming from academia, industry, and the creative sector. Participating laboratories in the Network are part of established research schools within renowned research organizations and Universities, with supervisors who are experts within their respective research field, publish regularly in high-impact journals and have received EURYI and ERC awards. This environment of excellence offers a multidisciplinary PhD program to 12 young researchers (ESRs), through training in the analysis of basic chemical and physical principles that underlie the correct timing and localization of events during DNA repair. In addition training will center around method development using methodology, equipment, software and experience provided first-hand by four small technology-driven companies. Individual research projects as well as personal training plans will be implemented for each ESR, incorporating a local training program, multiple rotations within partner laboratories, exposure to the non-academic sector and Network meetings. ESRs will follow scientific workshops, courses in transferable skills, career development and entrepreneurship, and will disseminate and communicate their projects to a diverse audience in close collaboration with the creative sector. DNAREPAIRMAN will result in a new generation of mature and innovative European scientists with a thorough understanding of fundamental quantitative principles underlying biology, with experience in technique development, and affinity for the academic as well as the non-academic research setting, providing a broad and promising career perspective.

Original text from CORDIS.

Participants

  • ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM · RotterdamCoordinatorNetherlands
  • ACADEMISCH ZIEKENHUIS LEIDEN · LeidenNetherlands
  • CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS · ParisFrance
  • ELVESYS · PARISFrance
  • FUTURESYNTHESIS SP ZOO · PoznanPoland
  • Institute of Bioorganic Chemistry · PoznanPoland
  • JPK INSTRUMENTS AG · BERLINGermany
  • JUSTUS-LIEBIG-UNIVERSITAET GIESSEN · GIESSENGermany
  • STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS · AmsterdamNetherlands
  • TgK Scientififc LtD · Bradford on AvonUnited Kingdom
  • UNITED KINGDOM RESEARCH AND INNOVATION · SWINDONUnited Kingdom
  • UNIVERSITY OF BRISTOL · BRISTOLUnited Kingdom
  • Willem de Kooning Academy · ROTTERDAMNetherlands

Links

Data: CORDIS, © European Union