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H2020Staff exchange2017–2022

CARBO-IMmap · Immune activity Mapping of Carbon Nanomaterials

Horizon 2020 — Marie Skłodowska-Curie Actions

Duration
2017-03-01 → 2022-02-28
EU contribution
€796,500
Participants
8
Scheme
MSCA-RISE

Lines connect the coordinator with its partners.

Results in brief

Immune activity Mapping of Carbon Nanomaterials

Long-term nanobiotechnology goal: The long-range goal of Carbo-IMmap is to develop a functional pipeline for the immune-characterization of carbon nanomaterials, for the qualitative and quantitative assessment in vitro and ex vivo of the human immune compatibility and immune activity of newly developed carbon materials. Long-term nanomedical goal: The functional pipeline will be used for the accurate immune mapping of graphene oxide, aminated graphene, exfoliated graphene, graphene nanoribbons, functionalized carbon nanotubes and carbon nanotube fibers. The accurate immuno-characterization of the tested materials on the basis of intrinsic physical-chemical features and immunological properties will open breakthrough perspectives for the development of new therapeutic approaches applying nanomaterials as immunomodulators, immunotherapetutic agents, molecular vectors and scaffolds for tissue regeneration/engineering. Key implementation aspects: The innovative pipeline will ground on computational modelling systems to predict the materials behaviours in the biological fluids and their interaction with biomolecules. The modelling strategy will be coupled with a wide array of high throughput assays based on immune-phenotypic and immune-genomics analysis providing the simultaneous detection of multiple effects on the five major immune cell populations and ex vivo on the highly complex immune blood cell pool. The combination of the most innovative technologies (12-colour Flow cytometry, ImageStream, CyTOF, single cell gene expression), allowing multiplex analysis of many cell types, will provide a forefront approach to investigate the immune impact. Scientific impact: The successful development and optimization of the functional pipeline for the characterization of the immune activity of newly synthesized, stable carbon nanomaterials will greatly advance the engineering process of carbon nanomaterials. The implication of this project extend beyond the specific nanoscience program. The unprecedented testing of 5 different types of materials to assess jointly the effect of different parameters (such as size and chemical functionalization) on all major type of immune blood cells, is a step ahead in basic research attempting to predict nanomaterial immune activity and to take advantage of their potential immunomodulation feature.

Data: CORDIS, © European Union

Project objective

The CARBO-IMmap project involves key players in Europe, US, Qatar and China with the aim to advance the field of carbon nanomaterial development and their exploitation biomedical applications. The long-range goal of Carbo-IMmap is to develop a functional pipeline for the immune-characterization of carbon nanomaterials, for the qualitative and quantitative assessment in vitro and ex vivo of the human immune compatibility and immune activity of newly developed carbon materials.The project aims to: 1) design and synthetize a panel of 5 types of highly stable and water-soluble nanomaterials, characterized by finely tuned properties by controlling their size and composition, and to obtain these nanomaterials in large amounts with nearly identical size and shape and degree of functionalization; 2) achieve a quantitative understanding of the immune activity (stimulation/ anergy/ suppression) of the selected materials upon the 5 subpopulations of the immune blood cells; 3) correlate the physicochemical properties (size and chemical functionalization) of the nanomaterials with their immune properties; 4) establish a consolidated network between leading EU and extra-EU institutes to provide a stimulating international environment for talented young researchers; 5) advance the level of R&D in participant countries and foster technology transfer and dissemination; 6) raise the awareness of the general public on the prospects of carbon nanomaterials in future biomedical applications. Scientists will be formed by ""training by research"" stays at host labs, leading to an interdisciplinary and international formation.Funding of this program will enable long-term, transformative research collaborations that will contribute to the integration and collaboration of research groups of 4 European Countries (Germany, Italy, France and Spain) and 3 key non-EU Countries: USA, China and Qatar.""

Original text from CORDIS.

Participants

  • UNIVERSITA DEGLI STUDI DI TRIESTE · TriesteCoordinatorItaly
  • ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOMATERIALES- CIC biomaGUNE · San SebastianSpain
  • CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS · ParisFrance
  • SHANGHAI JIAO TONG UNIVERSITY · SHANGHAIChina
  • SIDRA MEDICAL AND RESEARCH CENTER · DOHAQatar
  • TECHNISCHE UNIVERSITAET DRESDEN · DresdenGermany
  • UNIVERSITA DEGLI STUDI DI SASSARI · SassariItaly
  • WILLIAM MARSH RICE UNIVERSITY · Houston TexasUnited States

Links

Data: CORDIS, © European Union