CLIP · Comprehensive Lifestyle Intervention Project (CLIP)
Horizon 2020 — Marie Skłodowska-Curie Actions
- Duration
- 2017-01-01 → 2019-12-31
- EU contribution
- €257,191
- Participants
- 2
- Scheme
- MSCA-IF-GF
Lines connect the coordinator with its partners.
Results in brief
Comprehensive Lifestyle Intervention Project (CLIP)
Cardiovascular (CV) disease is the leading cause of death in Europe, and its prevalence continues to rise at an alarming rate largely because of behavioural risk factors (smoking, unhealthy diet, physical inactivity, obesity, etc.). CLIP (Comprehensive Lifestyle Intervention Project) was funded by a Marie Skłodowska-Curie Action from the European Union Horizon 2020 Research and Innovation Program. The Project tackled novel approaches to health promotion and CV disease prevention. Treatment of disease once symptoms are present represents a huge economic burden to societies and healthcare systems. This problem is anticipated to be exponentially magnified in the coming years due to the alarming increase in obesity (especially in children) and unhealthy lifestyles. One of the most effective ways to tackle this epidemic would be to implement preventive strategies before the disease appears [Image 1. Taken from Fernandez-Jimenez et al. J Am Coll Cardiol. 2018;72(25):3310-3319]. These preventive strategies apply to both adults and children. A key remaining problem is that advanced CV disease is recognized too late. The overall objectives of the project were to perform extensive and multidisciplinary training on innovative strategies for effective lifestyle modification in adults and children (24-month outgoing phase), and to transfer the new methodology to Europe by carrying out a pilot lifestyle-centered program in Spain (12-month incoming phase). The new abilities I acquired from various areas will enable me to implement new programmes to attain primary CV disease prevention after becoming an independent group leader upon my return to Europe at my host institution.
Data: CORDIS, © European Union
Project objective
Cardiovascular disease (CVD) incidence continues to rise at an alarming rate largely as a consequence of behavioural risk factors. The only way to tackle this epidemic is to implement preventive strategies before the disease appears. Current evidence suggests that conventional approaches are inadequate for promoting healthier lifestyles, and therefore implementation of novel methods is desperately needed. The research proposed under the acronym of CLIP (Comprehensive Lifestyle Intervention Project) will tackle novel approaches to CVD prevention based on the Personalized Medicine concept, considering the interactions between genetic and environmental factors of disease development.During the outgoing phase (24 months), the young Experienced Researcher (ER) will perform extensive and multidisciplinary training on innovative strategies for effective lifestyle modification in adults and children, and will undertake a specific study to identify genomic factors able to predict adult subjects who will benefit most from novel lifestyle interventions, thus permitting future tailored approaches. During the incoming phase (12 months) the ER will transfer the new methodology to Europe by carrying out a pilot lifestyle modification and genomic study program in adults in Spain. This experience will be enriched by the secondment in a private multinational company. Thus, the new abilities the ER will acquire from various areas will enable him to implement new programmes to attain primary CVD prevention, including the use of genomic-driven personalized approaches; and to become an independent group leader upon my return to Europe at the host institution. The long term impact of the CLIP will help to reduce the huge economic burden to society and healthcare systems associated with CVD treatment as it will directly contribute to Europe’s aim of fighting the CVD epidemic.
Original text from CORDIS.
Participants
- CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CARLOS III (F.S.P.) · MadridCoordinatorSpain
- ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · NEW YORKUnited States
Links
Data: CORDIS, © European Union