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H2020Doctoral network2017–2021

CAPICE · Childhood and Adolescence Psychopathology: unravelling the complex etiology by a large Interdisciplinary Collaboration in Europe

Horizon 2020 — Marie Skłodowska-Curie Actions

Duration
2017-02-01 → 2021-01-31
EU contribution
€3,163,688
Participants
10
Scheme
MSCA-ITN-ETN

Lines connect the coordinator with its partners.

Results in brief

Childhood and Adolescence Psychopathology: unravelling the complex etiology by a large Interdisciplinary Collaboration in Europe

Mental health symptoms impose a great burden on individuals, their families and on society as a whole. They often start in childhood and in around 50% of the children with mental health problems still have psychiatric symptoms in adulthood which are associated with increased rates of school dropout, unemployment and other negative functional outcomes. Improving the outcomes of these problems in childhood will therefore have a major impact. Both genetic and non-genetic factors play a role in mental health symptoms. Depending on age, gender and type of mental health symptoms, the heritability is between 40% and 80%, implying a larger contribution of environmental factors for some syndromes than for others. CAPICE brings together eight European cohorts. These cohorts have followed children and their families, often from birth and collected data on on lifestyle, family environment, health, and emotional and behavioral problems. Phenotypic and genome-wide genotypic data are available for over 60,000 children, in addition to genome-wide genotypes for over 20,000 mothers and epigenome-wide data for over 6,000 children. This wealth of data provides an excellent opportunity to elucidate the role of genetic and environmental factors, and their interplay in the occurrence of childhood psychopathology, its persistence, and its comorbidities. The focus will be on common mental health symptoms, such as anxiety, depression, and Attention Deficit Hyperactivity Disorder (ADHD). The network will also build capacity of allround researchers in psychiatric genetics that, from the start of their training work in an international network, as is nowadays the rule in this type of research, ensuring the sustainability of the consortium. At the end of this project, a stable international and interdisciplinary research network with a good data infrastructure will exist, enabling continuation of the high quality research. The results will provide targets for prevention and intervention, improving the health prospects for those young people with mental health symptoms

Data: CORDIS, © European Union

Project objective

In the Roadmap for Mental Health and Wellbeing Research in Europe (ROAMER), top-priority is research into child and adolescent mental health symptoms. CAPICE (Childhood and Adolescence Psychopathology: unravelling the complex etiology by a large Interdisciplinary Collaboration in Europe) will address this priority. This network will elaborate on the EArly Genetics and Lifecourse Epidemiology (EAGLE) consortium, a well-established collaboration of the many European birth and adolescent population based (twin and family) cohorts with unique longitudinal information on lifestyle, family environment, health, and emotional and behavioral problems. Phenotypic and genome-wide genotypic data are available for over 60,000 children, in addition to genome-wide genotypes for over 20,000 mothers and epigenome-wide data for over 6,000 children. Combined with the enormous progress in methodology, the results of the research performed in this network will greatly expand our knowledge regarding the etiology of mental health symptoms in children and adolescents and shed light on possible targets for prevention and intervention, e.g. by drug target validation. Moreover, it will provide Early Stage Researchers (ESRs) with an excellent training in the psychiatric genomics field given by a multidisciplinary team of eminent scientists from the academic and non-academic sector highly experienced in e.g., gene-environment interaction and covariation analyses, (epi)genome-wide association studies, Mendelian Randomization (MR) and polygenic analyses. With a focus on common and debilitating problems in childhood and adolescence, including depression, anxiety and Attention Deficit Hyperactivity Disorder, CAPICE will contribute to improving later outcomes of young people in European countries with child and adolescent psychopathology.

Original text from CORDIS.

Participants

  • STICHTING VU · AmsterdamCoordinatorNetherlands
  • ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM · RotterdamNetherlands
  • GOETEBORGS UNIVERSITET · GoeteborgSweden
  • IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE · LondonUnited Kingdom
  • JANSSEN-CILAG AKTIEBOLAG · SOLNASweden
  • KAROLINSKA INSTITUTET · STOCKHOLMSweden
  • KING'S COLLEGE LONDON · LondonUnited Kingdom
  • UNIVERSITA DEGLI STUDI DI CAGLIARI · CagliariItaly
  • UNIVERSITEIT TWENTE · EnschedeNetherlands
  • UNIVERSITY OF BRISTOL · BRISTOLUnited Kingdom

Links

Data: CORDIS, © European Union