ACTPD · Streamlined Functionalisation of Nitrogen-containing Molecules by Palladium-catalysed C-H Activation
Horizon 2020 — Marie Skłodowska-Curie Actions
- Duration
- 2017-03-10 → 2019-04-19
- EU contribution
- €183,455
- Participants
- 1
- Scheme
- MSCA-IF-EF-ST
Lines connect the coordinator with its partners.
Results in brief
Streamlined Functionalisation of Nitrogen-containing Molecules by Palladium-catalysed C-H Activation
Chemical reactions are highly valuable tools for scientists and for society since they provide useful materials not found in nature. The overall objective of the project is to develop novel chemical reactions for the synthesis of nitrogen-containing chemicals. This class of substances are vital for human health since they are commonly found in pharmaceuticals. Despite the advancements made in medical science over the past several decades, there is still a lack of effective treatment for many diseases. To meet the pressing demand for new cures, more facile syntheses of biologically active compounds are required. To this end, this project aimed to streamline the synthesis of nitrogen-containing molecules through the development of novel chemical reactions.
Data: CORDIS, © European Union
Project objective
Transition-metal catalysed C-H activation is a powerful tool to functionalise and derivatize organic molecules at seemingly inert sites. The strategy opens new efficient synthetic routes to existing molecules and provides access to novel ones. Our aim is to develop palladium catalysed sp3 C-H activation technology for the synthesis of nitrogen heterocycles and for the derivatization of simple secondary amines to high value molecules. Our proposal will address demand in the pharmaceutical industry for the efficient synthesis of nitrogen-containing molecules to aid medicinal chemistry and accelerate the drug discovery processes.
Original text from CORDIS.
Participants
- THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE · CAMBRIDGECoordinatorUnited Kingdom
Links
Data: CORDIS, © European Union