NOVA · Novel Antimicrobial Graphene Oxide-Lanthanide- Hydroxyapatite Composites as Therapeutic Materials in Bone Infection and Repair
Horizon 2020 — Marie Skłodowska-Curie Actions
- Duration
- 2017-03-01 → 2019-02-28
- EU contribution
- €195,455
- Participants
- 1
- Scheme
- MSCA-IF-EF-ST
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Results in brief
Novel Antimicrobial Graphene Oxide-Lanthanide- Hydroxyapatite Composites as Therapeutic Materials in Bone Infection and Repair
Orthopaedic infections are associated with long-term disability and together with antimicrobial resistance pose an increasing threat to public health. A review on the antimicrobial resistance estimated around 0.7M deaths worldwide each year with a possibility to rise to 10M a year by 2050 having a cumulative 66 trillion-pound economic impact due to the costs associated with the rise of drug-resistant infections. It is therefore vital and necessary to develop some alternative approaches for a better society. To build new multi-functional systems that can exhibit antimicrobial properties for bone related applications is both challenging and desirable. The overall aim is to develop antimicrobial lanthanide containing ceramic composites to address emerging bone and antimicrobial issues. WP 1: Development and characterisation of innovative Lanthanide glasses and doped HA WP 2: Development and characterisation of GO-Ln-HA composites WP 3: In vitro osteoblastic cell culture, cytotoxicity and antimicrobial studies of GO and GO-Ln-HA composites. The aims and objectives of NOVA have been successfully achieved and reported in Tech. Report Part B.
Data: CORDIS, © European Union
Project objective
NOVA is an innovative multi- and inter-disciplinary Fellowship hosted by the University of Birmingham in the UK with the main aim to develop antimicrobial graphene oxide (GO)-lanthanide glasses (Ln)-hydroxyapatite (HA) composites for bone repair. Large bone defects and infections represent a major challenge for orthopaedic surgeons. Infections may be life-threatening or, commonly, associated with long-term disability and pose a serious and increasing threat to public health, especially when antimicrobial resistance is becoming a serious problem. It is therefore highly desirable to develop novel multi-functional systems that can exhibit antimicrobial properties for bone repair. Lanthanide glasses (Ln) and Graphene Oxide (GO) have shown very interesting properties, the first being used in sensing and imaging as well as enabling cell attachment and isomorphic replacements for calcium, the second being an antimicrobial. NOVA will develop a multifunctional composite system combining the useful properties of a lanthanide host glass with the antimicrobial activity of Graphene Oxide and the bioactivity of Hydroxyapatite (HA). The proposed research is a novel research direction, and there is no previously published research on what is proposed to be a new class of multi-functional composites.
Original text from CORDIS.
Participants
- THE UNIVERSITY OF BIRMINGHAM · BirminghamCoordinatorUnited Kingdom
Links
Data: CORDIS, © European Union