EnanSET · Homogeneous and heterogeneous enantioselective Single Electron Transfer (SET) catalysis in cross-coupling reactions

Homogeneous and heterogeneous enantioselective Single Electron Transfer (SET) catalysis in cross-coupling reactions

Chirality of organic molecules plays a paramount role in our society as a consequence of the direct relation between the absolute molecular configuration and many properties and applications of molecular compounds and materials. The demand of enantiomerically pure compounds has increased considerably driven by the request of the pharmaceutical industry, as well as applications such as flavours, fragrances, and materials. In this context, the development of new methodologies to obtain enantiomerically pure compounds has become a challenge for the scientific community. The overall objective of EnanSET project is to developing novel enantioselective SET cross-coupling reactions of redox active esters (RAEs) by environmental friendly metal-complex due to this kind of compounds do not need previous activation. Additionally, inspired by demand of the industrial processes, the need to develop clean and green chemical processes in order to avoid environmental concerns and the advantages that heterogeneous catalysis provides, we will develop the first SET heterogeneous catalysis with MOFs through the postsynthetic incorporation of chiral Ni or Ti-residues on the pore structure. The scientific objectives described of this project are the following: A) Outgoing phase (Scripps Research Institute, La Jolla, California, USA) - Asymmetric Ni-complex synthesis and evaluation of its capacity to catalyze enantioselective cross-coupling reaction of redox-active ester (RAEs). - Development of Ti-catalysed cross-coupling of RAEs. - Enantioselective version of Ti-catalysed cross-coupling reactions. B) Incoming phase (University of Granada, Spain) -Chiral MOFs Synthesis and Asymmetric heterogeneous catalysis

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