BIO-CAPTURE · Biomechanical Characterization of Carotid Plaque Rupture
Horizon 2020 — Marie Skłodowska-Curie Actions
- Duration
- 2017-07-01 → 2019-06-30
- EU contribution
- €165,599
- Participants
- 1
- Scheme
- MSCA-IF-EF-RI
Lines connect the coordinator with its partners.
Results in brief
Biomechanical Characterization of Carotid Plaque Rupture
This project tackled an urgent health problem, arterial atherosclerosis, a major cause of cardiovascular events. Current clinical decisions for surgical intervention are made without assessing the plaque vulnerability as no reliable means for vulnerability assessment exists today. Biomechanics can help to develop useful risk assessment tools; yet, the fundamental knowledge on atherosclerotic plaque biomechanics are to great extent missing. The project aimed at biomechanical characterization of atherosclerotic arteries. This was done by combining experimental work, high-end plaque imaging and computational modelling. The project provided biomechanical characterization, more specifically material properties of atherosclerotic arteries, their structural organization and potential mechanisms for material failure.
Data: CORDIS, © European Union
Project objective
Stroke is the second leading cause of mortality worldwide. Most stroke events are triggered by an atherosclerotic plaque rupture in a carotid artery. Current clinical decisions for the carotid plaque removal surgery are made without assessing the plaque rupture risk as no reliable means exists today. Biomechanics can help to develop such risk assessment tools; yet, the fundamental knowledge on biomechanical descriptors of plaque rupture is missing.This project aims to provide biomechanical characteristics of atherosclerotic plaque rupture. This will be done by combining experimental work, high-end plaque imaging and computational modeling. First, non-existing biomechanical plaque rupture data will be collected from a novel experimental approach of physiological, ex-vivo inflation/rupture tests with atherosclerotic human carotid arteries. The pre-rupture and rupture strain distributions in plaques during the tests will be assessed in 3D via a cutting-edge high frequency ultrasound technique. With a novel inverse finite element (FE) technique, heterogeneous material properties of the plaques will be identified. This unique material information will be used in plaque-specific FE models to compute 3D pre-rupture and rupture stress distributions in the plaques. The assessed plaque strain and stress fingerprints will be evaluated for their predictive value of plaque rupture. The essential knowledge on biomechanical characteristics of plaque rupture will aid making more accurate surgical treatment decisions to prevent stroke-related mortality and morbidity. Besides the high-impact research, this fellowship will also result in enhancement of the applicant’s skill set through the valuable training on ultrasound imaging, histology and pathomorphology examination. Furthermore, the fellowship will allow him to return to the EU research environment, and bring back his expertise in tissue experimentation and modeling, and advanced FE analysis.
Original text from CORDIS.
Participants
- ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM · RotterdamCoordinatorNetherlands
Links
Data: CORDIS, © European Union