ADOC · Characterization and monitoring of vigilance fluctuation in disorders of consciousness
Horizon 2020 — Marie Skłodowska-Curie Actions
- Duration
- 2017-08-01 → 2019-11-10
- EU contribution
- €160,800
- Participants
- 1
- Scheme
- MSCA-IF
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Results in brief
Characterization and monitoring of vigilance fluctuation in disorders of consciousness
The clinical diagnosis of consciousness in patients with severe brain injury is mainly based on bedside observation of the patient's responses to the environment using standardized neurobehavioral scales. However, they are not all reliable and studies have revealed that about 40% of the patients are clinically misdiagnosed as being unconscious. In addition, as the probability to detect voluntary responses depends on the patient's level of vigilance at the time of assessment, multiple assessments are needed to detect signs of consciousness and, consequently, to avoid misdiagnoses. Misdiagnoses can lead to critical ethical consequences, especially in terms of end-of-life decision-making and pain treatment. In this project, we aimed at better characterize vigilance fluctuation (as defined by a change in behavioral responsiveness during the day) in patients with severe brain injury using neurophysiological parameters (i.e., eye responses, electroencephalography, actigraphy).
Data: CORDIS, © European Union
Project objective
This prospective exploratory study will aim at characterizing vigilance fluctuation in patients with disorders of consciousness (as defined by a change in diurnal behavioral response over time) using neurophysiological parameters. We based this project on the assumption that changes at the Coma Recovery Scale-Revised scores (i.e., behavioral responsiveness) will be associated with a change in ocular measures and EEG complexity, suggesting that some of these parameters could be used for monitoring vigilance in this population. We expect that this fluctuation will be particularly marked in patients with a minimally conscious state as compared with patients in an unresponsive wakefulness syndrome who will display a more stable pattern of response over the two days. This project aims to better understand the course of vigilance fluctuation in DOC and to develop an objective tool based on biomarkers that could be used at bedside to determine the best periods to assess and treat these patients.
Original text from CORDIS.
Participants
- UNIVERSITE DE LIEGE · LIEGECoordinatorBelgium
Links
Data: CORDIS, © European Union