CALLIRHEO · Multi-scale computational hemodynamics in obese children and adolescents: enabling personalised prediction of cardiovascular disease
Horizon 2020 — Marie Skłodowska-Curie Actions
- Duration
- 2018-03-01 → 2020-02-29
- EU contribution
- €183,455
- Participants
- 1
- Scheme
- MSCA-IF-EF-ST
Lines connect the coordinator with its partners.
Results in brief
Multi-scale computational hemodynamics in obese children and adolescents: enabling personalised prediction of cardiovascular disease
Childhood and adolescent obesity, primarily a dietary disease, has become a major challenge in recent decades. Obesity is known to accelerate the initiation of endothelial dysfunction, one of the key biological indicators of lesions of atherosclerosis that underlie most cardiovascular diseases. In line with recent European and worldwide policies on understanding childhood adiposity, the CALLIRHEO project aimed to develop an efficient multi-scale computational framework that would allow for the 3D blood flow analysis of young arteries. The project also aimed to perform patient-specific numerical simulations, correlated with medical data, for the investigation and assessment of flow-related disease markers. This research could have a significant impact for the society, in understanding obesity-induced vascular changes in children, and for the healthcare industry and medical science, in advancing novel methodologies. The scope and scientific objectives of the CALLIRHEO project were achieved within the timeframe of the project resulting in a considerable number of publications, public engagement activities, and application of a patent.
Data: CORDIS, © European Union
Project objective
Childhood obesity is currently at epidemic rates, with serious risks for cardiovascular disease in adulthood and premature death. Obesity is known to accelerate the initiation of endothelial dysfunction and alter the hemodynamics in young arteries. In alignment with urgent EU and worldwide policies on understanding childhood adiposity, we propose to develop a novel and safe computational tool to study numerically, for the first time, the obesity-altered hemodynamics in children and adolescents. The project aims to transfer the non-invasive computational fluid dynamic technology to the paediatric practice and enable personalised prediction of cardiovascular disease and effective decision-making. Within a multi-scale modeling framework, the proposed study seeks to utilise high-fidelity state-of-the-art numerical methods and develop new ones, for the implementation and coupling of the 3D flow in anatomically realistic arterial geometries with macroscopic and microscopic information, ensuring high stability and accuracy of results. In conjunction with clinicians, the study will perform patient-specific numerical simulations, correlated with medical data, and help towards individualized treatment planning, with a significant impact on the quality of life of the young patient. This multidisciplinary perspective is fundamental in elucidating early vascular changes induced by obesity and predict cardiovascular disease risks, while protecting the young population.
Original text from CORDIS.
Participants
- UNIVERSITY OF STRATHCLYDE · GlasgowCoordinatorUnited Kingdom
Links
Data: CORDIS, © European Union