ILMET · Metabolic characterization of ILCs under homeostatic or stress conditions.
Horizon 2020 — Marie Skłodowska-Curie Actions
- Duration
- 2017-09-01 → 2019-08-31
- EU contribution
- €173,076
- Participants
- 1
- Scheme
- MSCA-IF-EF-ST
Lines connect the coordinator with its partners.
Results in brief
Metabolic characterization of ILCs under homeostatic or stress conditions.
The increasing prevalence of obesity, and many other metabolic disorders, worldwide necessitates a better understanding of this class of diseases. Innate lymphoid cells (ILCs) are the most recently identified components of the innate immune system. They colonize different tissues sites and they play a crucial role in keeping the homeostatic balance, as well as in the context of infection, chronic inflammation, metabolic disorders and cancer. For example, the visceral adipose tissue (VAT) is populated also by two ILCs subsets: the natural killer (NK) cells and Group 2 innate lymphoid cells (ILC2). The latters have been shown to be crucial in regulating adipocytes homeostasis and controlling the development of metabolic unbalances. Our findings elucidate the mechanisms by which these cells adapt to the microenvironment, activate and exert their functions by using innovative approaches. While expanding the emerging discipline of immunometabolism and our knowledge of innate cells biology, our data serve as a tool that might help characterizing the functions of ILCs in metabolic disorders. Ultimately, pathways identified through our research may be exploited to block or enhance the activity of ILCs in order to identify new treatments for metabolic disorders.
Data: CORDIS, © European Union
Project objective
Innate lymphoid cells (ILCs) are the most recently identified components of the innate immune system. ILCs colonize mainly mucosa-associated tissues and they have a crucial role in metabolic homeostasis, and defense against infections and cancer. ILCs are highly plastic and they rapidly shape their functional output in response to local environmental cues. Two ILC subsets (ILC2 and NK cells) have been respectively implicated in the maintenance of adipose tissue homeostasis and in the development of chronic inflammation in obese patients. It has been shown that cellular metabolism affects the development and function of adaptive lymphocytes. In contrast, very little is known about innate lymphocytes metabolic requirements under homeostatic conditions and how they metabolically adapt to environmental perturbations.This project will study metabolic profiles in human ILC subsets isolated from the bloodstream, lymphoid and non-lymphoid tissues under healthy conditions and inflammatory disease states. Whole-genome transcriptomes, proteomes and metabolomes will be compared in order to decipher the pathways that regulate ILCs. A better understanding of the metabolic network that govern ILCs in steady state and how these cells “switch” their metabolism to exert their function, may ultimately reveal novel targets for the treatment of chronic inflammatory diseases and metabolic disorders, like obesity.
Original text from CORDIS.
Participants
- INSTITUT PASTEUR · ParisCoordinatorFrance
Links
Data: CORDIS, © European Union