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H2020Individual fellowship2017–2019

NeuroBaBEL · Whispering the language of the neurons to restore vision

Horizon 2020 — Marie Skłodowska-Curie Actions

Duration
2017-09-01 → 2019-08-31
EU contribution
€170,122
Participants
1
Scheme
MSCA-IF-EF-ST

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Results in brief

Whispering the language of the neurons to restore vision

By delivering controlled current into the eye, it is now possible to restore some level of vision to the blind. However, unlike its older brother the cochlear implant, the so-called bionic eye has not yet reached a level of maturity as to become a widely adopted therapy. Possibly, one of the major challenges researchers are facing is the necessity of controlling the neural messages elicited by these devices. The healthy eye codifies transitions of light, from on-to-off and from off-to-on. Nevertheless, with the current technologies, the message thus delivered informs the brain about the light being turned off and on simultaneously. In pursuing new methods to improve the communication between the device and the brain, this project aims to generate more meaningful neural messages that could bring bionic vision closer to bionic ear. This would dramatically improve the quality of life of the visually impaired community.

Data: CORDIS, © European Union

Project objective

Visual neuroprostheses or the bionic eyes, aim to restore patterned vision to the blind by electrically stimulating the remaining neurons in the visual system. The ultimate goal of bionic eye research as a means of treating vision loss is the capacity to reproduce the same neural messages that travel between the eye and the brain of normal vision. The visual system 'sees' the world by way of sending signals to the brain that indicate transitions from 'light ON to light OFF' and from 'light OFF to light ON' wherever a transition exists. Despite the remarkable progress over the last decade, until recently, visual neuroprostheses could only stimulate both the ‘ON-to-OFF’ and the ‘OFF-to-ON’ pathways simultaneously, sending confusing neural messages to the brain. Selective activation has been demonstrated in vitro while validated computational models predict that neural signals can be modulated by affecting these waveforms. This proposal aims to investigate, in a functional model of the disease (Royal College of Surgeons rats), new ways to preferentially activate the aforementioned visual pathways using amplitude- and frequency- modulated signals combined with low-power noise. It is expected that the resulting neural encoding to be more natural and to therefore improve the perception of the bionic eye recipients. Two strategies will be adopted: (1) acute electrophysiology experiments to obtain optimal stimulation parameters, and (2) chronic studies in behaving animals with retinal degeneration subjected to classical conditioning. This is a highly multidisciplinary proposal that includes a comprehensive plan for the dissemination of the results among the scientific community and the general public, while providing opportunities for industrial engagement. The fellow will be immersed in a motivating research environment and will be exposed to a series of training and networking activities which provide an excellent ground for future career perspectives.

Original text from CORDIS.

Participants

  • UNIVERSIDAD PABLO DE OLAVIDE · SevillaCoordinatorSpain

Links

Data: CORDIS, © European Union