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H2020Doctoral network2017–2022

DRIVE · Driving next generation autophagy researchers towards translation

Horizon 2020 — Marie Skłodowska-Curie Actions

Duration
2017-11-01 → 2022-04-30
EU contribution
€3,890,065
Participants
35
Scheme
MSCA-ITN

Lines connect the coordinator with its partners.

Results in brief

Driving next generation autophagy researchers towards translation

The manipulation of autophagy has an enormous therapeutic potential to revolutionize the way we currently treat cancers, neurodegenerative disorders, inflammatory and infectious diseases. Knowledge about the mechanism and regulation of autophagy is growing at a breakneck speed. However, translation of this knowledge into clinical-grade products with a benefit for the public healthcare has lagged behind. Translation is currently hampered by the lack of knowledge about the precise contribution of autophagy for different physiological and pathological situations, but also by the lack of models and biomarkers and assays to monitor autophagy in vivo. This gap does not allow to effectively test therapies and drugs and hampers the realization of clinical trials. Moreover, despite the great promises made by pioneering medical studies, the still limited applied research on autophagy has hampered the translation of fundamental knowledge into clinical-grade products and improved healthcare. Applied autophagy research is essential to understand the roles of autophagy in the different physiological and pathological situations, to generate (disease) models and develop biomarkers and assays to assess its progress. The ultimate goal of the ETN Driving next generation autophagy researchers towards translation (DRIVE) has been to train 15 young scientists through a tailored program, to fill these two gaps. Each one of them has realized a cutting-edge project in either an academic research group or company.

Data: CORDIS, © European Union

Project objective

The manipulation of autophagy has an enormous therapeutic potential to revolutionize the way we currently treat cancers, neurodegenerative disorders, inflammatory and infectious diseases. Despite the great promises made by pioneering medical studies, the still limited applied research on autophagy has hampered the translation of fundamental knowledge into clinical-grade products and improved healthcare. Applied autophagy research is essential to understand the roles of autophagy in the different physiological and pathological situations, to generate (disease) models and develop biomarkers and assays to assess its progress.The goal of the ETN Driving next generation autophagy researchers towards translation (DRIVE) is to train young scientists to fill this gap. DRIVE will equip its ESRs with an unique combination of knowledge and experimental expertise that are brought together in this consortium by the different partners. The realization of their projects in applied autophagy research will benefit of an exceptional interdisciplinary platform integrating cell biology, biochemistry, molecular biology, genetics, chemistry and “omics” approaches. In addition, DRIVE ESRs will acquire competencies to exploit the results for the development of products and techniques of commercial value. These ESRs will also be trained in disseminating results and knowledge through modern channels of communication.

Original text from CORDIS.

Participants

  • ACADEMISCH ZIEKENHUIS GRONINGEN · GroningenCoordinatorNetherlands
  • ADJUVATIS · LyonFrance
  • AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS · MadridSpain
  • ANAXOMICS BIOTECH SL · BarcelonaSpain
  • CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS · ParisFrance
  • COST action Transautophagy · BarcelonaUnknown Region
  • Club Francophone de l'Autophagie · Chatenay-MalabryUnknown Region
  • EBERHARD KARLS UNIVERSITAET TUEBINGEN · TuebingenGermany
  • ELSEVIER BV · AmsterdamNetherlands
  • ENYO PHARMA · LYONFrance
  • FRAUNHOFER GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG EV · MunchenGermany
  • GBM Studiengruppe Autophagy · TuebingenUnknown Region
  • HELSINGIN YLIOPISTO · HelsinkiFinland
  • IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE · LondonUnited Kingdom
  • INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE · ParisFrance
  • INSTITUTE OF CANCER RESEARCH: THE ROYAL CANCER HOSPITAL LBG · LondonUnited Kingdom
  • KING'S COLLEGE LONDON · LondonUnited Kingdom
  • Network of Ecellence for Autophagy Research · MadridUnknown Region
  • Nordic Autophagy Network · OsloUnknown Region
  • Pfizer · New YorkUnknown Region
  • QPS NETHERLANDS BV · GRONINGENNetherlands
  • REGENTS OF THE UNIVERSITY OF MICHIGAN · ANN ARBORUnited States
  • RHEINISCH-WESTFAELISCHE TECHNISCHE HOCHSCHULE AACHEN · AachenGermany
  • SPRINT BIOSCIENCE AB · HUDDINGESweden
  • Stichting Healthy Ageing Network Northern Netherlands · GroningenNetherlands
  • TURUN YLIOPISTO · TurkuFinland
  • Takeda Millennium · CambridgeUnknown Region
  • Technology and Transfer Office · ROTTERDAMUnknown Region
  • The Edmond & Lily Safra Children's Hospital, Sheba Medical Centre · Ramat GanUnknown Region
  • UNIVERSIDAD POMPEU FABRA · BarcelonaSpain
  • UNIVERSITAETSKLINIKUM FREIBURG · FreiburgGermany
  • UNIVERSITETET I OSLO · OsloNorway
  • WEIZMANN INSTITUTE OF SCIENCE · RehovotIsrael
  • Wenckebach Institute · HEERLENUnknown Region
  • e.mersion studioUnited States

Links

Data: CORDIS, © European Union