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H2020Staff exchange2018–2023

CanBioSe · Novel 1D photonic metal oxide nanostructures for early stage cancer detection

Horizon 2020 — Marie Skłodowska-Curie Actions

Duration
2018-01-01 → 2023-12-31
EU contribution
€1,116,000
Participants
15
Scheme
MSCA-RISE

Lines connect the coordinator with its partners. CORDIS does not always give exact coordinates for projects before 2014. These points are placed at city or country level.

Results in brief

Novel 1D photonic metal oxide nanostructures for early stage cancer detection

The CanBioSe project research and innovation goals are targeted to develop a new portable tool for early stage cancer detection which can solve one of the important health challenges in EU society. The project is targeted to strengthen international and intersectoral collaboration, sharing new ideas, knowledge transfer from research to market, and vice versa in the field of nanostructured metal oxide optical biosensors for cancer cell detection. The project partners will provide research and training activities in the fields of nanotechnology, surface functionalization, bioengineering, microfluidics and biosensor testing, market analysis and commercialisation. The provided research and management training to experienced researchers and early stage researchers will be quite beneficial. It will strengthen their personal skills and CVs via the new scientific papers and conference theses and strengthen a development of EU research human resources. We foresee a long lasting collaboration between the partners, based on co-supervising students and the preparation of novel collaborative project proposals. Also foreseen is a dissemination of the project results to the scientific society and wide auditories. Scientific work will include: One dimensional (1D) polimer nanofibers will be deposited by an electrospinning technique. Photonic nanomaterials, based on metal oxide based nanostructures (ZnO, ZnO/Al2O3 nanolaminates, Au/ZnO and ZnO/Au) will coat the 1D nanofibers. Metal oxides and Au nanoparticles will be deposited with Atomic Layer Deposition (ALD) and electrophoresis, respectively. Bioselective layer will be formed by immobilization of specific antibodies on the biosensor surface. Photoluminescence and optical spectroscopy will be used for recording the biosensor signal. Biosensor testing will be performed on cancer cells (human chronic lymphocyte leukemia (CLL) leucosis and acute lymphoblastic leucosis). The biosensor will be integrated with microfluidic system in order to minimize dimensions and simplify the use of the detection system.

Data: CORDIS, © European Union

Project objective

The project CanBioSe targeted to strengthen international and intersectoral collaboration, sharing new ideas andknowledge transfer from research to market and vice versa in the field of nanostructured metal oxide optical biosensors forcancer cells detection. Interdisciplinary project research and innovation goals are targeted to develop a new portable tool forearly stage cancer detection which can solve on of important health challenges in EU society. One dimensional (1D) polimernanofibers will be deposited by electrospinning technique. Photonic nanomaterials, based on metal oxide basednanostructures (ZnO, ZnO/Al2O3 nanolaminates, Au/ZnO and ZnO/Au) will coat the 1D nanofibers. Metal oxides and Aunanoparticles will be deposited with Atomic Layer Deposition (ALD) and electrophoresis, respectively. Bioselective layer willbe formed by immobilization of specific antibodies on the biosensor surface. Photoluminescence and optical spectroscopywill be used for recording of the biosensor signal. Biosensor testing will be performed on cancer cells (human chroniclymphocyte leukemia (CLL) leucosis and acute lymphoblastic leucosis). The biosensor will be integrated with microfluidicsystem in order to minimize dimensions and simplify the use of the detection system.The project partners will provide research and training activities in the fields of nanotechnology, surface functionalization,bioengineering, microfluidics and biosensor testing, market analysis and commercialization. Provided research andmanagement training to experienced researchers and early stage researchers will strengthen their personal skills and CVsvia new scientific papers and conference theses and strengthen a development of EU research human resources. Longlasting collaboration between partners, based on co-supervising students and preparation of novel collaborative projectproposals is foreseen. Dissemination of the project results to scientific society and wide auditories is foreseen.

Original text from CORDIS.

Participants

  • LATVIJAS UNIVERSITATE · RIGACoordinatorLatvia
  • 3D STRONG, SIA · UlbrokaLatvia
  • BIOSENSOR SRL · FormelloItaly
  • CSD HEALTH CARE · KYIVUkraine
  • ECOLE NATIONALE SUPERIEURE DE CHIMIE DE MONTPELLIER · MONTPELLIER CEDEX 5France
  • EESTI MATERJALITEHNOLOOGIATE ARENDUSKESKUSE OÜ · TartuCity levelEstonia
  • FONDAZIONE BRUNO KESSLER · TrentoItaly
  • Institute of Biophysics and Cell Engineering, National Academy of Sciences of Belarus · MinskCity levelBelarus
  • MATERIALS RESEARCH CENTER · KievUkraine
  • MB SENSOGRAFA · VilniusLithuania
  • NANO PRIME SPOLKA Z OGRANICZONA ODPOWIEDZIALNOSCIA · DEBICAPoland
  • NANOPHARMA AS · PardubiceCzechia
  • STATE INSTITUTION REPUBLICAN SCIENTIFIC AND PRACTICAL CENTER FOR TRANSFUSIOLOGY AND MEDICAL BIOTECHNOLOGIES · MINSKCity levelBelarus
  • UNIWERSYTET IM. ADAMA MICKIEWICZA WPOZNANIU · PoznanPoland
  • VILNIAUS UNIVERSITETAS · VilniusLithuania

Links

Data: CORDIS, © European Union