MATRIX-B · Triaxial Magnetic Fields for the Control of Bioactive Materials in Bone Engineering
Horizon 2020 — Marie Skłodowska-Curie Actions
- Duration
- 2018-09-01 → 2020-08-31
- EU contribution
- €170,122
- Participants
- 1
- Scheme
- MSCA-IF-EF-ST
Lines connect the coordinator with its partners.
Results in brief
Triaxial Magnetic Fields for the Control of Bioactive Materials in Bone Engineering
The Action “Triaxial Magnetic Fields for the Control of Bioactive Materials in Bone Engineering” (MATRIX-B) looks at utilise triaxial magnetic (TM) fields, with 3 degrees of freedom, to obtain a new generation of three-dimensional field-responsive biomaterials for orthopedic diseases. The research seeks to study new configurations that allow the simultaneous generation and control of magnetic fields in three-dimension (3D), thus being able to control very precisely and remotely the self-assembly of magnetic particles in polymeric solution, producing extraordinarily well-controlled microscale structures. Also, intends to control improved mechanical properties of new biomaterials, since magnetorheology under TM fields is still a completely unexplored field of research. This approach is opening up new perspectives on the ability to specifically control a biomaterial "on demand". Such topics are important because society needs new therapeutic approaches to impulse and assist tissue regeneration in patients with reduced endogenous regenerative potential, as treatment of bone defects are still clinical challenges. Life expectancy will continue to increase, yet unhealthy life years for each individual make up around 20% of a person's life. To replace the insufficiency of organs and tissues in the clinic and opt for a non-invasive medicine, novel tissue engineering approaches are emerging to meet regenerative medicine demands and challenges. In this respect, the use of magnetic fields is appealing as remote signaling for non-invasive controlling and ready activation of smart biomedical devices. The ability to handle, simultaneously and precisely, magnetic fields in the 3D opens up new perspectives on the ability to specifically control a biomaterial. Objectives of this Marie Skłodowska Curie Action (MSCA) have been to (a) prepare and characterize magnetic particles and biocompatible fluids; (b) study of colloidal self-assembly under TM fields and related mechanical properties; and (c) test the response in vitro and in vivo of magnetic fluids exposed to triaxial magnetic fields. Another important parallel goal of the MSCA is to foster the development of the individual researcher.
Data: CORDIS, © European Union
Project objective
Magnetic tissue engineering envisions the development of complex systems in which magnetic elements are exploited as remotely controlled multidimensional tools with potential for diagnostic and therapeutic actions. Such a magnetic material can be imagined as a fixed “station” that offers a long-living assistance to tissue engineering, providing thus a unique opportunity to adjust the material activity to the personal needs of the patient. In the development of biomaterials for bone repair one of the major concerns is to increase their integration and remodeling rate. The possibility of favoring bone tissue engineering applications by magnetic stimulation in patients with reduced endogenous potential is a key issue, in consideration of the progressive ageing of the population for which more effective and personalized regenerative therapies will be increasingly demanded in the incoming decades. The original main driving idea of this project is the use triaxial magnetic fields for the creation of a conceptually new type of bioactive materials able to be manipulated directly in situ. To date all studies with magnetic biomaterials have been carried out only in presence of uniaxial fields. The very novelty of this project is the enhanced magnetic susceptibility in three dimensions by applying a triaxial magnetic field to a magnetic particles suspension. In principle, with such a configuration it is possible to magnetically drive the self-assembly of the particles producing extraordinarily well-controlled structures at the microscale. This novel approach, involving the use of triaxial fields, is expected to culminate in a new generation of materials with a specific, continuous and reloaded control from an external supervising center and new characteristics in tissue engineering, such as multiple uses, possibly multipurpose delivery and, furthermore, improved mechanical properties since magnetorheology under triaxial fields is still completely unexplored field of research.
Original text from CORDIS.
Participants
- UNIVERSIDAD DE GRANADA · GranadaCoordinatorSpain
Links
Data: CORDIS, © European Union