NeMESIS · Neuron-based Monitoring Electrochemical Bio-Sensor Interface System
Horizon 2020 — Marie Skłodowska-Curie Actions
- Duration
- 2019-02-01 → 2021-01-31
- EU contribution
- €183,455
- Participants
- 1
- Scheme
- MSCA-IF-EF-ST
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Results in brief
Neuron-based Monitoring Electrochemical Bio-Sensor Interface System
The project explored emerging technologies (memristive nanoscale devices) in an unconventional role (bio/chemical-sensing) ultimately targeting the development of a miniaturized sensing platform implementing memristive nanoscale devices as intelligent bio-sensing interfaces, a very new area and technological advancement in the medical and biosensing research. The main objectives were the realization and validation of this new bio-sensing platform and the implementation for the real-time detection of inflammation markers. The project delivered a good publications record, despite the COVID challenges and the slow initial set-up, due to labs availability and delays with arranging access to experimental facilities. The project successfully achieved: • Development and validation of the chemristor (from chemical- memristor), a modified version of the memristor with the added capability of interfacing chemical signals to a device with an inherent dynamic response, thus providing monitoring of bio-electrochemical processes. • Demonstration of memristor-based sensing platform reconfigurability overcoming longstanding bottleneck in realizing this, is various non-idealities that generate offsets and variable responses across sensors (Sci. Rep. 10(1), 1-6, 2020). • Showcasing the biosensing capabilities and performance for cancer markers detection at the range within the clinical range of interest [ng/ml] (Sci. Rep. 10(1), 1-6, 2020). • Showcasing real-time continuous monitoring function and successful application for detection of inflammatory markers (C-reactive protein) achieving a Limit-of-detection of 0.18 pg/mL, when the CRP Limit-of-detection achieved with ELISA was 300 pg/ml. The paper related to these project outcomes is currently under review-submitted January 2021)
Data: CORDIS, © European Union
Project objective
Reliable, real-time detection systems for in-vivo, continuous monitoring of biological and chemical processes consist a crucial aspect in personalised healthcare. Nevertheless, even nowadays, the medical practice still lacks of systems providing a rapid, reliable and ultra-sensitive sensing in a continuous way. Meanwhile, inflammatory markers consist a pivotal tool in clinical practice since they may be indicators of specific diseases, along with signalising the response of a patient to a specific medical treatment. Nanotechnology-based devices exhibiting memristive electrical properties show great potential for delivering highly scalable, resilient, power efficient and reconfigurable electronic systems. In addition, when those particular nanodevices are subjected to appropriate surface treatments and implemented in the role of bio-inspired sensors, they can bring solutions and introduce novelty to the bio-sensing field regarding highly sensitive and robust detection of biomarkers, while expanding and broadening the research field and applications involving memristive phenomena. In the framework of this fellowship, a flexible, low-cost miniaturised minimally invasive sensing platform will be developed, implementing memristive nanoscale devices as intelligent bio-interfaces, allowing reliable, continuous and real-time monitoring of inflammatory markers. This scheme will be accomplished by the fabrication of a memristor-based sensing platform conjugated with a sensing membrane and an accordingly designed binding assay. Validation of the sensing platform for continuous monitoring will be followed by the integration on flexible substrates for in vivo measurements and integration with readout circuitry enabling the sensing data readout and the wireless transmission to a tablet or smartphone. Finally, the sensing platform will be applied for in-vivo, real-time monitoring, for the detection of inflammatory markers and for indicating the response to an applied treatment.
Original text from CORDIS.
Participants
- UNIVERSITY OF SOUTHAMPTON · SOUTHAMPTONCoordinatorUnited Kingdom
Links
Data: CORDIS, © European Union