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H2020Individual fellowship2019–2021

MAGNET-CELLPATCH · Multimodal magnetic cellular-patches with synergistic effects for high performance theranostics

Horizon 2020 — Marie Skłodowska-Curie Actions

Duration
2019-09-01 → 2021-08-31
EU contribution
€158,122
Participants
1
Scheme
MSCA-IF-EF-ST

Lines connect the coordinator with its partners.

Results in brief

Multimodal magnetic cellular-patches with synergistic effects for high performance theranostics

In order to advance in the design of the multifunctional agents with enhanced theranostic efficency, it has been proposed the fabrication of different hybrid platforms that have the capacity to integrate different active modules. As it was highlighted in the MAGNET-CELLPATCH proposal, it is of utmost importance to minimize the chaotic aggregation effects of magnetic nanoparticles (MNPs) to achieve both a remarkable magnetothermal efficiency and a proper synergy among the different modules of the system. Globally, one of the most common type of cancer is the colorectal cancer (CRC), after lung and breast cancers. In average more than 1 million people get colorectal cancer every year, which develops into hepatic metastasis in 70% of the cases and it is usually not curable. Consequently, there is an urgent need in this field to develop new materials with enhanced theranostic efficacy. The transfer of the gained scientific knowledge to the clinical practice can promote progress and open new lines of work aimed at combating different types of tumors and diseases. Additionally, the theranostic platforms that have been developed during the project are completely adjustable to address the demands of the incipient “personalized medicine” that consists of adapting treatment to the genomic characteristics of each patient. In addition, the use of these kind of novel theranostic agents would save on expenses to treat collateral damage provoked by the conventional therapies. Overall, the objectives of this project is to design, fabricate and study novel multifunctional theranostic platforms with high biomedical potential. For that purpose several properties of the platforms have to be improved, such as: -Magnetothermal actuation -Endocytosis resistance -Dual-imaging -Specific Targeting -Biocompatibility -Etc. Two type of theranostic platforms have been proposed to accomplished the goals of the project: Platform I (MNPs individually coated by PEGylation technology) and Platform II (two-dimensional microdiscs with a monolayer of MNPs).

Data: CORDIS, © European Union

Project objective

The key goals of the MAGNET-CELLPATCH project are: a) the training of a talented experienced researcher, Dr. Castellanos-Rubio, in the fast growing fields of nanotechnology, microfabrication, biomedicine and healthcare industry, in which the host and partner institutions have an extensive knowledge and expertise; and, b) the development, optimisation and evaluation of cost-efficient multimodal magnetic cellular-patches for high performance theranostics. The interdisciplinary training program includes the use of advanced characterisation techniques, as XAS and SAXS, and the evaluation of the material in therapy (hyperthermia-chemotherapy) and diagnosis (MRI) of colorectal cancer. The fellow is a skilled researcher that during her undergraduate and postgraduate career has gained strong experience in the fabrication and characterization of biocompatible magnetic nanoparticles and inorganic-polymeric microstructures with magnetothermal properties. To further boost her career, she needs to gain expertise in sophisticated data-capture instrumentation (such as synchrotron radiation sources), in in-vitro and in-vivo experimental studies and in MRI technique, in which the UPV/EHU has a world-recognised expertise. Moreover, through secondments at academic and industrial co-hosts, at the UCL and NIT respectively, she will gain additional training in preclinical experiments in the field of magnetic-drug-targeting and in production protocols of medical devices, scaling-up options, cost-reduction strategies, quality-controls and market-ready items designs. This multidisciplinary project explicitly addresses a world-wide societal challenge in health, namely, the development of new materials for cancer treatment. In addition, it will also increase the fellow´s supervision and teaching experience, project and intellectual property management expertise, research funding and proposal writing, which will assist her in acquiring necessary competences to reach professional maturity.

Original text from CORDIS.

Participants

  • UNIVERSIDAD DEL PAIS VASCO/ EUSKAL HERRIKO UNIBERTSITATEA · LeioaCoordinatorSpain

Links

Data: CORDIS, © European Union