UCLnProt · De novo design of an UpConverting metalloProtein

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Project objective

Herein, we propose to design de novo (“from scratch”) the first upconverting metalloprotein. This will be achieved byexploiting a new class of lanthanide coiled coils (LCC), to generate bimetallic derivatives. These will, for the first time,combine the attractive photophysical properties of Ln complexes, with de novo designed coiled coil scaffolds capable ofselectively binding different Ln ions at well-defined and tuneable distances. This programme of work will provide a newstrategy for unlocking the full potential of science at the interface of biology and inorganic chemistry, by combining previouslyunexplored ligands with traditional inorganic complexes, for applications beyond those offered by biology, such asupconversion. The complementary expertise of Dr Sinha (bioinorganic synthesis and computational modeling) and thesupervisor Dr Peacock (metallopeptide design) offer the unique combination to realise the full potential of multimetallicLCCs, and will, in conjunction with two planned short secondments, provide Dr Sinha with new and cutting-edge researchtraining.

Original text from CORDIS.

Participants

• THE UNIVERSITY OF BIRMINGHAM · BirminghamCoordinatorUnited Kingdom

Links

• View on CORDIS
• DOI: 10.3030/799573