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H2020Doctoral network2019–2022

BonePainII · A European Training Network to Combat Bone Pain

Horizon 2020 — Marie Skłodowska-Curie Actions

Duration
2019-01-01 → 2022-12-31
EU contribution
€4,291,665
Participants
12
Scheme
MSCA-ITN

Lines connect the coordinator with its partners.

Results in brief

A European Training Network to Combat Bone Pain

Musculoskeletal pain affects the quality of life of millions and represents a major unmet medical need and a huge socio-economic challenge. It is a major cause of loss of earnings and has huge health care costs. In the BonePainII network, we focused on the painful disorders osteoarthritis, cancer in the bone, osteoporotic fractures, rheumatoid arthritis, and fibrous dysplasia, a rare bone disease. In a strong interdisciplinary and integrated effort across sectors, we trained a new generation of 15 creative, entrepreneurial and innovative early stages researchers. The overall objective was in three inter-related and integrated work packages to provide novel technologies and knowledge to enable drug discovery in bone pain.

Data: CORDIS, © European Union

Project objective

In Europe 20 - 30% of adults are affected at any one time by musculoskeletal pain such as arthritic pain, lower back pain, pain from osteoporotic fractures and bone metastasis, and also most rare bone diseases are very painful. Despite a huge negative impact on the quality of life of the patients and on society as a whole, no specific treatment is yet available. Therefore, there is a strong need to train highly skilled researchers within bone pain and thereby make the foundation for improved therapies. In this proposal we bring together 3 industrial beneficiaries, 8 academic beneficiaries, and one industrial partner all committed to train a new generation of 15 creative, entrepreneurial and innovative early stages researchers in bone pain research and transferable skills. The early stages researchers will train with some of the foremost neuroscientists and bone researchers in academia and industry across Europe. The BonePainII training network will provide the early stage researchers with expertise that will enable them to gain high level employment both in academia and industry. In a multidisciplinary, intersectoral and integrated project we will develop advanced 3D microfluidic in vitro platforms and high throughput techniques to investigate bone-neuron interactions; validate and investigate novel in vivo models of bone pain including a rare bone disease; and using cutting-edge technologies to identify key mechanisms underlying bone pain in osteoarthritis, rheumatoid arthritis, and cancer-induced bone pain.

Original text from CORDIS.

Participants

  • KOBENHAVNS UNIVERSITET · KOBENHAVNCoordinatorDenmark
  • ASTRAZENECA UK LIMITED · CAMBRIDGEUnited Kingdom
  • CELLECTRICON AB · MolndalSweden
  • INEB-INSTITUTO NACIONAL DE ENGENHARIA BIOMEDICA · PortoPortugal
  • KAROLINSKA INSTITUTET · STOCKHOLMSweden
  • KING'S COLLEGE LONDON · LondonUnited Kingdom
  • NATURWISSENSCHAFTLICHES UND MEDIZINISCHES INSTITUT AN DER UNIVERSITAET TUEBINGEN · ReutlingenGermany
  • NORDIC BIOSCIENCE A/S · HerlevDenmark
  • THE ROYAL VETERINARY COLLEGE · LondonUnited Kingdom
  • TRANSPHARMATION LTD · LondonUnited Kingdom
  • UNIVERSITAIR MEDISCH CENTRUM UTRECHT · UtrechtNetherlands
  • UNIVERSITY COLLEGE LONDON · LondonUnited Kingdom

Links

Data: CORDIS, © European Union