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H2020Doctoral network2019–2023

INSPiRE-MED · INtegrating Magnetic Resonance SPectroscopy and Multimodal Imaging for Research and Education in MEDicine

Horizon 2020 — Marie Skłodowska-Curie Actions

Duration
2019-01-01 → 2023-06-30
EU contribution
€3,946,286
Participants
23
Scheme
MSCA-ITN

Lines connect the coordinator with its partners. CORDIS does not always give exact coordinates for projects before 2014. These points are placed at city or country level.

Results in brief

INtegrating Magnetic Resonance SPectroscopy and Multimodal Imaging for Research and Education in MEDicine

Medical Imaging plays a central role in modern healthcare systems by the development of the most advanced techniques such as Magnetic Resonance Imaging (MRI) / Magnetic Resonance Spectroscopy (MRS) and Positron Emission Tomography (PET). Furthermore, development of multi-parametric MR and hybrid imaging (MR/PET) by combining non-invasive metabolic information of MRS (MRSI) with high sensitivity given by radiotracers of PET is crucial for the improvement of diagnosis and treatment monitoring of diseases. Therefore, the clinical translation of these powerful hybrid techniques is necessary to focus on different diseases such as cancer and neurodegenerative brain diseases and requires high level of expertise in several methodological domains: 1) Acquisition of multi-parametric and multimodal MRS(I)/PET data, 2) Image and spectra processing, and 3) Data analysis using machine learning approaches. The major objective of the INSPiRE-MED project was to train 15 Early-Stage Researchers (ESR) in a complex and challenging branch of medical imaging, namely MRS(I) combined with PET, which requires a solid background in physics for acquisition developments and/or in computer science for data analysis using latest machine-learning methods, to develop (pre-)clinical applications. These goals were achieved by: 1. Providing core scientific knowledge, essential to break down barriers between basic research and clinical use based on high experience of INSPiRE-MED partners: • New acquisition methods of pre- and clinical imaging, • New version of data processing software (jMRUI), • New ML and DL methods for clinical diagnosis and prognosis. 2. Guiding the ESRs into this integrated scientific culture by training events: • “hands-on” research training and workshops, • Complementary “soft” skills courses from local institutions and SME industrial partners, • Exchange with medical doctors. 3. Creating new relationships between academic research, health practice and health industry: • Training in successful academic or industrial environments through secondments, • Organizing joint-programs between software developments and clinical applications.

Data: CORDIS, © European Union

Project objective

INSPiRE-MED will provide research and training to 15 early career researchers in the field of medical imaging, specifically Magnetic Resonance Spectroscopy (MRS) and Spectroscopic Imaging (MRSI), combined with MR Imaging and Positron Emission Tomography (PET). INSPiRE-MED Fellows will acquire skills to develop careers contributing to innovative technological advances in medical imaging in a multi-disciplinary environment encompassing physics, mathematical and computer sciences leading to applications in medicine and biological sciences. The 12 academic and 9 industrial partners will provide the Fellows with transferable and generic skills as well as a comprehensive, wide-ranging education on the basic principles of medical imaging and image analysis. This fundamental knowledge will be combined with in-depth learning in a specific area, through local delivery via graduate schools, programme-wide INSPiRE-MED training activities and workshops and personal academic supervision by two INSPiRE-MED supervisors. This will enable them to successfully participate in developing new tools for clinicians. MRS is a unique, non-invasive molecular technique that has proved useful for diagnosis and therapy management in disease models and patients. Despite its potential, the clinical uptake of MRS has lagged behind that of MRI and PET. Thus, INSPiRE-MED will have 3 objectives, encapsulated in 3 research Work Packages (WP):1) Development of novel acquisition and processing techniques allowing MRS(I) to become a key tool in medical imaging (WP1); 2) Integration of innovative MRS(I) techniques in several key clinical and pre-clinical applications including a multimodal metabolic approach based on MR/PET (WP2); 3) Translation of most advanced research in MRS(I) and machine learning into clinical routine by means of a fully automatic software suite, building on the well-known jMRUI package (http://www.jmrui.eu) to provide a prime tool in personalized medicine (WP 3).

Original text from CORDIS.

Participants

  • UNIVERSITE LYON 1 CLAUDE BERNARD · Villeurbanne CedexCoordinatorFrance
  • BRUKER BIOSPIN MRI GMBH · EttlingenGermany
  • CENTRE D'ETUDE ET DE RECHERCHE MULTIMODAL ET PLURIDISCIPLINAIRE EN IMAGERIE DU VIVANT GIE · Bron CedexFrance
  • CONSORCIO CENTRO DE INVESTIGACION BIOMEDICA EN RED M.P. · MadridSpain
  • ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE · LausanneSwitzerland
  • Fealinx · BrignaisFrance
  • GENERAL ELECTRIC DEUTSCHLAND HOLDING GMBH · Frankfurt Am MainGermany
  • ICOMETRIX NV · LeuvenBelgium
  • INSEL GRUPPE AG · BernSwitzerland
  • KATHOLIEKE UNIVERSITEIT LEUVEN · LeuvenBelgium
  • MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV · MUNCHENGermany
  • MR COILS BV · ZaltbommelCity levelNetherlands
  • NORGES TEKNISK-NATURVITENSKAPELIGE UNIVERSITET NTNU · TrondheimNorway
  • PHILIPS MEDICAL SYSTEMS NEDERLAND BV · BestNetherlands
  • SIEMENS HEALTHCARE GMBH · ErlangenGermany
  • STICHTING RADBOUD UNIVERSITAIR MEDISCH CENTRUM · NijmegenNetherlands
  • STICHTING RADBOUD UNIVERSITEIT · NijmegenNetherlands
  • THE UNIVERSITY OF MANCHESTER · ManchesterUnited Kingdom
  • UNIVERSITAET BERN · BernSwitzerland
  • UNIVERSITAET LEIPZIG · LeipzigGermany
  • UNIVERSITAIR MEDISCH CENTRUM UTRECHT · UtrechtNetherlands
  • UNIVERSITAT AUTONOMA DE BARCELONA · Cerdanyola Del VallesSpain
  • USTAV PRISTROJOVE TECHNIKY AVCR VVI · BRNOCzechia

Links

Data: CORDIS, © European Union