GreenX4Drug · Green Enantioselective Halogenation for Drug Discovery and Manufacture

Green Enantioselective Halogenation for Drug Discovery and Manufacture

Issue Addressed: The European pharmaceutical industry confronts challenges such as patent expirations and stricter environmental regulations, prompting a shift towards sustainable practices. GreenX4Drug has tackled these issues by pioneering eco-friendly methodologies for pharmaceutical synthesis. Importance for Society: GreenX4Drug meets societal demands for accessible healthcare and environmental responsibility. By developing greener manufacturing processes, the project reduces the ecological impact of pharmaceutical production while addressing public health needs. Objectives: 1. Develop "Green" Organocatalysts: GreenX4Drug aims to create efficient organocatalysts, reducing reliance on expensive and harmful metal catalysts in pharmaceutical synthesis. 2. Establish Halogenation Platform: The project seeks to demonstrate the versatility of these catalysts in halogenation processes, providing a synthetic platform for pharmaceutical compound preparation. 3. Synthesise Drugs: Production of halogenated pharmaceuticals and intermediates. 4. Scale-up: Demonstrating industrial viability by scaling up synthesis using batch and continuous flow methodologies. Conclusions: GreenX4Drug has pioneered sustainable pharmaceutical manufacturing, addressing societal healthcare needs while promoting environmental stewardship. By leveraging academic and industry expertise, the project developed cost-effective and eco-friendly processes with the potential to transform the industry. While some deviations occurred, the project substantially achieved its scientific objectives, including the successful development of novel chiral scaffolds and methodologies for fast and selective synthesis of halogenated compounds. Ongoing evaluations aim to maintain enantiopurity, with adaptations for continuous flow methodology showing promise for scaled-up production.

Data: CORDIS, © European Union