LOBSTER · Development of Photochemical Strategies for the Generation and Use of Sulfur Radicals in the Assembly of C-S Bonds
Horizon 2020 — Marie Skłodowska-Curie Actions
- Duration
- 2019-05-01 → 2021-08-31
- EU contribution
- €224,934
- Participants
- 1
- Scheme
- MSCA-IF-EF-ST
Lines connect the coordinator with its partners.
Results in brief
Development of Photochemical Strategies for the Generation and Use of Sulfur Radicals in the Assembly of C-S Bonds
• What is the problem/issue being addressed? This Fellowship aimed at delivering transformative advances towards the assembly of sulfur-containing molecules of interest to the pharmaceutical and agrochemical industry sectors. The project was based on the use of visible-light as the source of energy for the generation and use of sulfur radicals in organic synthesis. The main aspect was the design of a novel class of derivatives able to undergo single electron transfer with photoexcited catalyst and then lead to S–O bond fragmentation as blueprint for S-radical formation. • Why is it important for society? This project aims at delivering fundamental advances for the preparation of sulfur-containing molecules (thioether, sulfones, sulfonamides...), which are fundamental to the discovery and evolution of drugs, agrochemicals and food additives. Improving the way we make these molecules underpins the manufacture of high-value materials that impact positively our lives. • What are the overall objectives? 1) Develop a novel class of derivatives based on the presence of weak S–O bonds that could be activated by visible-light irradiation 2) Develop novel divergent and multicomponent processes cyclization of sulfur radicals 3) Use sulfur radicals for the intriduction of S-functionalities onto aromatics
Data: CORDIS, © European Union
Project objective
Sulfur-containing molecules are widespread as medicines, agrochemicals and organic materials. Their preparation could be greatly facilitated by implementing sulfur-radicals, which are a class of very versatile synthetic intermediates. However, to date, difficulties associated to their generation and controlling their reactivity have severely limited their use and exploitation in synthetic settings. Here we propose the development of two conceptually novel and general ways to prepare sulfur-radicals using visible-light. These processes will capitalize on recent developments in the host group that has disclosed two novel organocatalytic ways for the generation of nitrogen-radicals. This proposal seeks to substantially expand this photochemical approach by developing methods for the generation and use of sulfur-radical. The power of this approach will be demonstrated by fast generation of 3D molecules containing atoms of sulfur. These methods will be then integrated with other reaction platforms that, taking advantage of visible-light as source of energy, will engage the sulfur-radical in new reactivity modes, to allow novel and powerful multicomponent thio-functionalization reactions. Furthermore, we will harness these activation modes to enable the direct thiolation of aromatic compounds in a single step without the use of transition metal catalysts.Through the use of this strategy, the rapid construction of many relevant and complex –sulfur-containing molecules will be possible. The development of such an innovative and ambitious project at the University of Manchester will be facilitated by generating, transferring, sharing and disseminating knowledge, and will enhance my career development following the training plan envisioned.
Original text from CORDIS.
Participants
- THE UNIVERSITY OF MANCHESTER · ManchesterCoordinatorUnited Kingdom
Links
Data: CORDIS, © European Union