GRASAD · Uncovering the genetic roots of ASD and ADHD
Horizon 2020 — Marie Skłodowska-Curie Actions
- Duration
- 2020-09-01 → 2022-08-31
- EU contribution
- €160,932
- Participants
- 1
- Scheme
- MSCA-IF
Lines connect the coordinator with its partners.
Results in brief
Uncovering the genetic roots of ASD and ADHD
Autism Spectrum Disorder (ASD) and Attention-Deficit/Hyperactivity Disorder (ADHD) are common neurodevelopmental and childhood-onset chronic disorders. Despite being notably impairing and presenting deleterious effects on reproductive success they both are highly prevalent. Although they have distinct diagnostic definitions, they can co-occur in the same individual and they present a substantial overlap of symptoms. One of the hypotheses explaining the co-occurrence between ASD and ADHD proposes that they may have, at least in part, a common aetiology, which is supported by recent genetic studies. The goal of GRASAD was to study two important and still unsolved issues regarding the genetic underpinnings of ASD and ADHD. On one side, this project aimed at understanding how a diverse set of genetic risk factors are involved in both ASD and ADHD and ultimately to specific symptoms shared between the two disorders. On the other side, we also aimed to study evolutionary aspects of the genetic roots of ASD. In disorders such as ASD and ADHD, in which the set of genes involved has been estimated to be large and heterogeneous, it is crucial to identify risk genes that cut across disorders and may be relevant to specific disease symptoms. This is essential for the development of improved diagnostic procedures, to gain insight into the prognosis of the disorder and also for the development of new and effective pharmacological treatments. Moreover, studying these disorders from an evolutionary perspective can provide a more natural view of the disorder and help to understand why they are so prevalent today.
Data: CORDIS, © European Union
Project objective
Autism Spectrum Disorders (ASD) and Attention-Deficit/Hyperactivity Disorder (ADHD) are common neurodevelopmental and childhood-onset chronic disorders. Although ASD and ADHD do have distinct diagnostic definitions, evidence has accumulated to suggest substantial overlap between their symptoms. Despite of being notably impairing and presenting deleterious effects on reproductive success they both are highly prevalent. The goal of GRASAD is the study of two important remaining unsolved issues regarding the genetic underpinnings of ASD and ADHD taking advantage of the most innovative approaches in the neurogenetics field. On one side, GRASAD-I will apply state-of-the-art methodologies to address the question of which and how a diverse set of genetic risk factors are involved in both ASD and ADHD and subsequently to specific symptoms shared between both disorders. On the other side, GRASAD-II will study evolutionary aspects of the genetic roots of ASD from a genomics perspective to shed light on the so-called paradox of psychiatric disorders: given that these disorders are considered maladaptive and have heritable risk, why do they still exist? This study is relevant due to it will not only pave the way for a more precise scientific understanding of ASD and its overlap with ADHD but also can have an impact on psychiatric practice within a precision medicine framework. The evolutionary perspective of the project can generate new hypotheses and guide research, inform treatment strategies, provide a more natural view of disease and elucidate the aetiology of mental illness and suffering. The multidisciplinary nature of the project is strong, involving a combination of well-developed novel approaches in the field of psychiatric genetics. This proposal includes both the transfer of knowledge to the host institution and the training of the candidate in new methodologies. This project is line with the EU strategy on Mental Health and Well Being.
Original text from CORDIS.
Participants
- UNIVERSITAT DE BARCELONA · BarcelonaCoordinatorSpain
Links
- View on CORDIS
- DOI: 10.3030/841899
- https://webgrec.ub.edu/webpages/000011/cat/marina.mitjans.ub.edu.html
Data: CORDIS, © European Union