PHOTALLICA · 1,2-Dicarbofunctionalization of Alkenes by Merging Photoredox and Transition-Metal Catalysis
Horizon 2020 — Marie Skłodowska-Curie Actions
- Duration
- 2019-05-01 → 2021-04-30
- EU contribution
- €162,806
- Participants
- 1
- Scheme
- MSCA-IF
Lines connect the coordinator with its partners.
Results in brief
1,2-Dicarbofunctionalization of Alkenes by Merging Photoredox and Transition-Metal Catalysis
"Humanity's modern way of living is borne by the production of chemicals, which include functional materials (such as polymers), agrochemicals and pharmaceuticals. Among the H2020 societal challenges, the ""climate action, environment, resource efficiency and raw materials"" item aims to diminish society's chemical footprint. It addresses the importance of developing more efficient, less wasteful and responsible ways for the production of chemical goods. The use of catalytic reactions for the synthesis of molecules has the advantage of being more sustainable, as they have lower energy consumption, shorter reaction times and use less reactive starting materials, among others. In line with this, the discovery of novel catalytic transformations that use feedstock starting materials, such as unsaturated hydrocarbons, is one of the most direct way of accessing functionalized carbon skeletons that are present in value-added molecules. The overarching objective of this project was to develop new chemical reactions for the functionalization of double carbon-carbon bonds using dual transition-metal/photoredox catalysis, aiming for the generation of disubstituted carbon chains in an efficient and mild way. This action delivered two new catalytic transformation using the aforementioned methodology for the synthesis of value-added compounds that can be used to produce for example polymers, agrochemicals or pharmaceuticals."
Data: CORDIS, © European Union
Project objective
PHOTALLICA aims to develop a general approach towards the 1,2-dicarbofunctionalization of unactivated alkenes to afford highly functionalized carbon skeletons. The outlined strategy is based on a 3-component cross-coupling reaction in which the reactivity of the coupling partners is governed by merging a photoredox and a transition-metal catalytic cycle. The specific objectives of this action are to give access to 1,2-arylalkyl, 1,2-dialkyl and 1,2-diaryl substitution patterns starting from unactivated alkenes, radical precursors, and electrophiles or nucleophiles as the coupling partners, as well as to study the mechanism of the developed transformations. The products are vicinal substituted alkyl chains, which are prevalent motifs in biologically active compounds. The action aligns with H2020 societal challenges that seek to improve resource efficiency and the use of raw materials as –as opposed to the state-of-the-art strategies– it avoids the use of pre-functionalized alkenes by using feedstock olefins, instead. The background in transition-metal catalyzed transformations of the candidate (Eloísa Serrano, ES), together with the expertise of the host (Prof. Frank Glorius, FG, Westfälische Wilhelms-Universität Münster, Germany) on the development dual photoredox strategies, make an ideal combination to realize PHOTALLICA. The developed transformations will have an impact on the way α-olefins, which are produced on multi-ton scale by the chemical industry, are functionalized by providing a more efficient disconnection approach towards vicinal substituted alkyl scaffolds. By developing the action in a dynamic and renowned research group, the candidate will acquire new skills in project management, mentoring, leadership and communication.
Original text from CORDIS.
Participants
- UNIVERSITAET MUENSTER · MuensterCoordinatorGermany
Links
Data: CORDIS, © European Union