ARDRE · Ageing, Regeneration, and Drug Research
Horizon 2020 — Marie Skłodowska-Curie Actions
- Duration
- 2019-08-01 → 2025-07-31
- EU contribution
- €1,301,760
- Participants
- 1
- Scheme
- MSCA-COFUND
Lines connect the coordinator with its partners.
Results in brief
Ageing, Regeneration, and Drug Research
Aging is linked to a functional decline in organismic function throughout most living organisms, including both animals and plants. Age-related decline in tissue function is counter-acted by regeneration processes restoring tissue functions in aged organisms. However, regenerative capacity is limited in higher organisms including humans, and the reasons for these limitations are not well understood. The project aims at better understanding molecular mechanisms underlying aging and regeneration, which will allow to develop new drugs and drug-like compounds to improve regeneration and help to reduce the pathological burden of age-associated diseases. As life expectancy and the proportion of elderly people increase, effective measures to promote healthy ageing are urgently needed. The scientific aims of ARDRE are to explore molecular mechanisms leading to severe disabilities associated with old age, and identify small molecules with the potential to prevent their development. Innovative new insights are expected through the exploration of evolutionarily conserved molecular mechanisms of ageing and regeneration across kingdoms, comprising life forms as distant as plants and fungi, nematodes and tunicates to fish and mice, and finally humans. The ultimate goal is to develop regenerative strategies for reversing age-related damage to various tissues and organ systems. Conclusions of the action ARDRE: Work in ARDRE has provided significant new knowledge in the areas of aging research, regeneration research and drug research. Due to the combination of all three areas in an integrated project we have been able to combine new insight into processes of aging and regeneration with state-of-the-art technology for drug development. The combined results of ARDRE research create a great opportunity for the development of new products and procedures in the fields of aging and regeneration, to cope with global trends in the fields of aging, obesity, and neurodegenerative diseases.
Data: CORDIS, © European Union
Project objective
The main purpose of the Ageing, Regeneration, and Drug Research doctoral programme (ARDRE-DP) consortium is to set up a PhD training network of the highest level possible with regard to recruitment, training and mentoring of early career scientists as laid down in the European Charter for Researchers and the Code of Conduct for the Recruitment of Researchers. The ARDRE-DP is dedicated to equip the PhD students with the scientific competence and soft skills, including ethical aspects, required to succeed in the contemporary competitive scientific community globally. The students will benefit from the highly productive ARDRE team of scientists, who have complementary expertise and novel research tools available to study cellular mechanisms of ageing and regeneration. ARDRE will explore evolutionarily conserved mechanisms of ageing and regeneration from various phyla across the kingdom of life. The aim is to discover new molecules, including natural compounds involved in, or potentially counteracting ageing or regeneration, and to unravel molecular mechanisms leading to disabilities associated with old age. This is important considering the urgent need to combat the pressing issues related to our ever-increasing segment of elderly people. Recruitment of 12 early stage researchers will be organised in two subsequent calls. Each of the four years' doctoral projects will include up to six months of international secondment activity. The beneficiary, the University of Innsbruck (UIBK), is committed to support research into ageing, stem cell and regeneration biology, and drug discovery, taking advantage of the powerful existing expertise in the Faculty of Biology and the Faculty of Chemistry and Pharmacy. The ARDRE-DP will be complemented by an ancillary network of partner organisations from the academic and non-academic sector, providing further opportunities for international and inter-sectoral training of the PhD students.
Original text from CORDIS.
Participants
- UNIVERSITAET INNSBRUCK · InnsbruckCoordinatorAustria
Links
- View on CORDIS
- DOI: 10.3030/847681
- https://ec.europa.eu/research/participants/documents/downloadPublic?documentIds=080166e5c823291b&appId=PPGMS
- https://ec.europa.eu/research/participants/documents/downloadPublic?documentIds=080166e5ccee2fc5&appId=PPGMS
- https://www.uibk.ac.at/projects/dp-ardre/
Data: CORDIS, © European Union