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H2020Doctoral network2019–2023

DohART-NET · Periconceptional Programming of Health Training Network

Horizon 2020 — Marie Skłodowska-Curie Actions

Duration
2019-07-01 → 2023-11-30
EU contribution
€3,398,006
Participants
20
Scheme
MSCA-ITN

Lines connect the coordinator with its partners.

Results in brief

Periconceptional Programming of Health Training Network

Altered conditions during the periconceptional (PC) period of gamete maturation and early embryonic development have long lasting effects on the health of the progeny, including the childhood, adolescent and adult-life onset of cardiovascular, metabolic and neurological diseases (DOHaD concept). Increasing evidence from epidemiological and animal model studies shows that children worldwide exhibit conditions and disease risks associated with the exposures of their parents, including chemical stressors before and during pregnancy, reproductive failure, adverse pregnancy outcome, diabetes, obesity and nutritional compromise. Babies born following human Assisted Reproductive Technology (ART, “test-tube”) interventions render this population (over 8 million world-wide) one of the largest well-defined clinical cohorts to be studied for a better understanding of the future risk of disease for current and succeeding generations in Europe. The DohART-NET project focuses on the integration of pre-clinical (animal and stem cell-models) and clinical studies and applies data linkage, bioinformatics and network science for the identification and validation of mechanisms of diseases common in early development. We will exploit our new understanding to promote efficient disease prevention and potential personalised therapeutic interventions in both the general and ART populations to overcome adverse disease pathways.

Data: CORDIS, © European Union

Project objective

Altered conditions during the periconceptional (PC) period of gamete maturation and early embryonic development have long lasting effects on the health of the progeny, including the childhood, adolescent and adult-life onset of cardiovascular, metabolic and neurological diseases (‘Developmental Origins of Health and Disease (DOHaD) concept). Increasing evidence from epidemiological and animal model studies shows that children worldwide exhibit conditions and disease risks associated with the exposures of their parents, including chemical stressors before and during pregnancy, reproductive failure, adverse pregnancy outcome, diabetes, obesity and nutritional compromise. Babies born following human ART (“testtube”)interventions render this population (over 5 million world-wide) one of the largest well-defined clinical cohorts to be studied for a better understanding of the future risk of disease for current and succeeding generations in Europe. The DohART-NET project focus on the integration of pre-clinical (animal and stem cell-models) and clinical studies and apply data linkage, bioinformatics and network science for the identification and validation of mechanisms of diseases common in early development. We will exploit our new understanding to promote efficient disease prevention and potential personalised therapeutic interventions in both the general and ART populations to overcome adverse disease pathways. DohART-NET is optimized for training ESRs due to the facts that: i) the topic is progressive and much needed to improve public health over several generations, and it is integrating basic pre-clinical, translational clinical and in silico modeling approaches, iii) the partnership has a highly multi- and interdisciplinary scientific and training expertise and excellence, iv) there is an existing synergy by collaborations and links that the partners wish to strengthen both in science and lasting training programs in a highly inter-sectorial setting.

Original text from CORDIS.

Participants

  • BIOTALENTUM TUDASFEJLESZTO KFT · GoedoelloCoordinatorHungary
  • CEMM - FORSCHUNGSZENTRUM FUER MOLEKULARE MEDIZIN GMBH · WienAustria
  • CERTARA UK LIMITED · LondonUnited Kingdom
  • ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM · RotterdamNetherlands
  • IVI VALENCIA SL · VALENCIASpain
  • LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN · PlaneggGermany
  • MARIE CURIE ALUMNI ASSOCIATION · Bruxelles / BrusselBelgium
  • MEDICAL WOMEN'S INTERNATIONAL ASSOCIATION · Geneve 6Switzerland
  • MEDIZINISCHE UNIVERSITAET WIEN · WienAustria
  • MWM BIOMODELS GMBH · TiefenbachGermany
  • SCIPHER MEDICINE CORPORATION · Waltham MaUnited States
  • SICHUAN UNIVERSITY · CHENGDUChina
  • SZENT ISTVAN EGYETEM · GodolloHungary
  • THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE · CAMBRIDGEUnited Kingdom
  • THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD · OxfordUnited Kingdom
  • THE UNIVERSITY OF MANCHESTER · ManchesterUnited Kingdom
  • UNIVERSITAT DE VALENCIA · ValenciaSpain
  • UNIVERSITAT WIEN · WienAustria
  • UNIVERSITY OF SOUTHAMPTON · SOUTHAMPTONUnited Kingdom
  • VRIJE UNIVERSITEIT BRUSSEL · Bruxelles / BrusselBelgium

Links

Data: CORDIS, © European Union