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H2020Staff exchange2019–2024

SALSETH · Innovative bio-inspired sensors and microfluidic devices for saliva-based theranostics of oral and systemic diseases

Horizon 2020 — Marie Skłodowska-Curie Actions

Duration
2019-12-01 → 2024-11-30
EU contribution
€828,000
Participants
9
Scheme
MSCA-RISE

Lines connect the coordinator with its partners. CORDIS does not always give exact coordinates for projects before 2014. These points are placed at city or country level.

Results in brief

Innovative bio-inspired sensors and microfluidic devices for saliva-based theranostics of oral and systemic diseases

The problem/issue being addressed. To provide and maintain the appropriate oral hygiene and consequently general health, it is necessary to develop biodegradable sensors and intraoral appliances based on microfluidics technology with natural fluids (essential oils). Importance for society. One of the goals of the SALSETH project is the development of new intraoral appliances for oral and systematic theranostics, which is crucial for improving oral and systemic human health. The intraoral appliance should be developed utilizing microfluidic techniques, as the space available in the oral cavity is relatively small. The device must be fabricated using non-toxic materials. Digestible or biodegradable materials would be a good direction. Each appliance should be dedicated to an individual user, meaning that it could be disposable. The overall project objective is to create an international and inter-sectoral network of leading organisations working on a joint research programme in the domains of novel biodegradable sensors, microfluidic devices and essential oils for theranostics (therapy + diagnostic) in oral and systemic diseases. Three Specific Research Objectives (SROs) have been achieved: SRO1: To develop sensors from edible materials for monitoring of important biomarkers from saliva SRO2: To manufacture and test microfluidic chips and intraoral/orthodontic appliances for theranostics SRO3: To make new essential oils and to apply them in oral cavity using microfluidic-based intraoral appliances In addition, three Knowledge sharing objectives (KSOs) have been achieved: KSO1: To facilitate the exchange, flow and co-creation of knowledge within the consortium KSO2: To develop transferable skills and to stimulate entrepreneurship, boosting career prospects of involved staff members KSO3: To increase excellence of R&I activities contributing to higher Europe’s competitiveness and growth

Data: CORDIS, © European Union

Project objective

Oral hygiene is the cornerstone of good oral health and World Health Organization recognizes oral health as an integral part of systemic health. Among the non-invasive organic fluids, saliva is one of the most preferable and practical specimens for oral and systemic health monitoring as it is readily available and easily collected and stored. Saliva is frequently called a “mirror of the body” since it can reflect both the physiological and pathological conditions in the entire human organism. The SALSETH project proposal facilitates exchange of knowledge, skills, competencies and capabilities (through secondments) of 8 internationally top-ranking participating organizations (4 from academic sector and 4 SMEs) from Germany, Italy, Spain, Poland, Serbia, Ukraine, Malaysia and Australia. This project proposal promotes international and intersectoral collaboration between participating institutions, bringing experts from different fields of science in a unique R&I set up. The SALSETH brings together expertise of the respectable institutions to reach beyond the-state-of-the-art advances in: (1) natural and bio-inspired biocompatible materials; (2) edible food-based sensors which can promptly detect important biomarkers from saliva; (3) external smart electronic device for wireless reading data from sensors; and (4) microfluidic devices for optimal administration of drugs or essential oils as a main part of the intraoral appliances for better oral and systemic health. Through carefully designed secondments, the seconded staff will work on significant technological breakthrough in salivary theranostics for personalized dental bio-medicine. This interdisciplinary project offers an excellent research oriented environment for the personal and professional growth of the involved staff members. The SALSETH will open possibilities of salivary diagnostics for personalized individual medicine applications including clinical treatment options and outcome evaluation predictions.

Original text from CORDIS.

Participants

  • UNIVERZITET U NOVOM SADU · Novi SadCoordinatorSerbia
  • AYUS GMBH · BühlCity levelGermany
  • CURTIN UNIVERSITY · PerthAustralia
  • DREXEL UNIVERSITY · PhiladelphiaUnited States
  • MATERIALS RESEARCH CENTER · KievUkraine
  • Naturality Research & Development · Terrassa BarcelonaSpain
  • POLITECHNIKA WROCLAWSKA · WroclawPoland
  • UNIVERSITY OF MALAYA · Kuala LumpurMalaysia
  • WEST AQUILA SRL · L AQUILAItaly

Links

Data: CORDIS, © European Union