VIDEC · Visualizing Death Inducing Protein Complexes
Horizon 2020 — Marie Skłodowska-Curie Actions
- Duration
- 2020-01-01 → 2025-06-30
- EU contribution
- €1,237,400
- Participants
- 13
- Scheme
- MSCA-RISE
Lines connect the coordinator with its partners. CORDIS does not always give exact coordinates for projects before 2014. These points are placed at city or country level.
Results in brief
Visualizing Death Inducing Protein Complexes
The project contributes to the international and inter sectoral integration of European research through a programme that supports researcher mobility between European countries, Third Countries and between industry and academia. This mobility supports knowledge exchange and researcher training through projects focused on human diseases and drug-development, with the aim of finding new treatments for disease. This research is also more widely relevant to areas that include increased food security by improving aquaculture and better protection from chemical hazards by improved methods of toxicity assessment. The disease research focusses on problems particularly relevant to an aging population (like Europe’s) and include neurodegenerative diseases (e.g., Parkinson’s disease), cancer (e.g., Diffuse Large B Cell Lymphoma), and inflammation. This is being accomplished by studying how proteins bind to each other to cause human disease and then searching form drug-like chemicals to block the binding and cure the disease. The specific protein-protein interactions being investigated are the binding of Apaf-1 to itself and to caspase-9, the binding of CARD11 to BCL10, the binding of RIPK1 to RIPK1, the binding of NLRP3 to itself and to caspase-1, the binding of ASC to caspase-1 and the binding of caspase-2 to RAIDD. The overall objective is to identify at least one drug-like molecule that blocks a protein-protein interaction and that reduces or prevents disease-associated changes.
Data: CORDIS, © European Union
Project objective
Every day billions of cells die in our bodies as part of normal healthy processes. These cell deaths are called “regulated cell deaths” as they occur through the activation of genetically encoded molecular machinery. However, too little or too much cell death is the cause of various diseases and of illness caused by exposure to chemicals. Understanding these cell death processes and how they are controlled may lead to new treatments for disease as well as explaining why some chemicals are hazardous. Regulated cell deaths as exemplified by apoptosis, necroptosis, and pyroptosis are induced by the formation of protein complexes. Here, we will develop new molecular tools to visualize the formation of the protein complexes in live cells and tissues and then use these tools to study cell death in normal and disease processes. Our consortium includes cell death experts, bioluminescence experts, zebrafish experts, as well as structural, developmental, molecular and cell biologists in industry and academia. The proposed research network will provide intersectoral mobility between laboratories expert in complementary skills. This will drive the development of the new tool and enhance the researchers’ career prospects. The research is of importance to many citizens of the EC; it will contribute to increasing food security by improving aquaculture, improving the health of aging populations through the study of degenerative diseases, improving toxicity assessment to better protect citizens from chemical hazards and improving the drug-development by better identification of adverse effects. Moreover, the assays emerging from the research will be commercialized by the industrial partners in the network, so supporting economic development within the EU.
Original text from CORDIS.
Participants
- UNIVERSITY OF GALWAY · GalwayCoordinatorIreland
- GOETEBORGS UNIVERSITET · GoeteborgSweden
- INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE · ParisFrance
- NORGES MILJO-OG BIOVITENSKAPELIGE UNIVERSITET · AsNorway
- OLYMPUS CORPORATION · Hachioji-Shi TokyoCountry levelJapan
- PROTOQSAR 2000 SL · ValenciaSpain
- RIJKSUNIVERSITEIT GRONINGEN · GroningenNetherlands
- TARBIAT MODARES UNIVERSITY (INSTRUCTOR'S TRAINING UNIVERSITY) · TEHRANIran
- THE GOVERNORS OF THE UNIVERSITY OF ALBERTA · EdmontonCanada
- THERACULE AS · OSLOCity levelNorway
- UNIVERSITE DE GENEVE · GeneveSwitzerland
- UNIVERZITA PALACKEHO V OLOMOUCI · OlomoucCzechia
- ZECLINICS SL · SANT FELIU DE LLOBREGATSpain
Links
Data: CORDIS, © European Union