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H2020Doctoral network2020–2024

STRATEGY-CKD · System omics to unravel the gut-kidney axis in Chronic Kidney Disease.

Horizon 2020 — Marie Skłodowska-Curie Actions

Duration
2020-02-01 → 2024-07-31
EU contribution
€3,363,591
Participants
12
Scheme
MSCA-ITN

Lines connect the coordinator with its partners.

Results in brief

System omics to unravel the gut-kidney axis in Chronic Kidney Disease.

Chronic kidney disease (CKD) remains a major public health problem. CKD is projected to be the 5th leading cause of years of life lost by 2040. Cardiovascular disease (CVD) is the major cause of death in CKD patients The accumulation of uremic toxins (UTs) in is an important risk factor for CVD in CKD. Several of these uremic toxins find their origin in the gut. Addressing the gut microbial metabolism could offer a cost-effective therapy for improving CKD outcomes. Early-stage researchers (ESRs) were trained to gain excellent scientific and transferable skills with exposure to both academic and nonacademic environments. This training now allows them to tackle complex diseases, to build bridges between researchers and entrepreneurs and to support the future translation of research findings in innovative therapies. Different training activities have been organized and attended in cooperation with complementary research consortia to synergistically improve structural training on European level, building a network. On top of that ESRs were encouraged to engage in scientific outreach to create awareness for CKD and to share their scientific findings with peers, colleagues and the general public.

Data: CORDIS, © European Union

Project objective

System omics to unravel the gut-kidney axis in Chronic Kidney Disease:There is a great need for multi-disciplinary and methodologically well trained scientists in order to unravel complex diseases. Chronic kidney disease (CKD), which is more prevalent in women, and its high risk for cardiovascular disease (CVD) with nearly 50% of all deaths in CKD patients caused by CVD, is such a complex disease and its socio-economic burden is extremely high. STRATEGY-CKD will in this context focus on the gut-kidney axis and the role of the intestinal microbiome as important contributor to the genesis and evolution of CVD in CKD and as possible therapeutic target to improve outcome of CKD patients. For this purpose, 10 leading multidisciplinary academic and 3 industrial investigators and their teams will train young researchers in (1) excellent scientific skills, integrating technological skills [in vitro, bacterial and animals molecular and functional studies, state-of-the-art omic (cultur-, microbi, peptid-, prote-, metabolomics) approaches, bioinformatics, systems biology] in clinical/mechanistic knowledge to generate innovative insights triggering the pathogenesis and treatment of CKD related CVD; (2) Excellent complementary skills in personal and career development as well as business training required to extend beyond scientific research; and (3) exposure to both academic and non-academic environments, required to build bridges between researchers and entrepreneurs and support the future translation of research findings in innovative therapies and services.STRATEGY-CKD builds on already available advanced technology, models and patient samples, and established collaborations. STRATEGY-CKD links to ongoing European programs among partners of the consortium. STRATEGY-CKD will stimulate the development of young, broadly-trained scientists able to successfully link basic to clinical research in academia as well as in industry unravelling complex diseases such as CVD-CKD.

Original text from CORDIS.

Participants

  • UNIVERSITEIT GENT · GentCoordinatorBelgium
  • IDRYMA IATROVIOLOGIKON EREUNON AKADEMIAS ATHINON · AthinaGreece
  • INSTITUTO INVESTIGACION SANITARIA FUNDACION JIMENEZ DIAZ · MadridSpain
  • KATHOLIEKE UNIVERSITEIT LEUVEN · LeuvenBelgium
  • MOSAIQUES DIAGNOSTICS GMBH · HannoverGermany
  • RD NEPHROLOGIE SAS · MontpellierFrance
  • UNIVERSITA DEGLI STUDI DELLA CAMPANIA LUIGI VANVITELLI · CasertaItaly
  • UNIVERSITAETSKLINIKUM AACHEN · AachenGermany
  • UNIVERSITATSKLINIKUM HEIDELBERG · HeidelbergGermany
  • UNIVERSITE D'AIX MARSEILLE · MarseilleFrance
  • UNIVERSITEIT UTRECHT · UtrechtNetherlands
  • VIB VZW · ZWIJNAARDE - GENTBelgium

Links

Data: CORDIS, © European Union