H2020Staff exchange2020–2025

cONCReTE · DevelOpmeNt of Cancer RNA TherapEutics

Horizon 2020 — Marie Skłodowska-Curie Actions

Duration: 2020-05-01 → 2025-10-31
EU contribution: €2,060,800
Participants: 17
Scheme: MSCA-RISE

Lines connect the coordinator with its partners.

Project objective

Non-codingRNAs (ncRNAs) represent a large class of molecules that in concert regulate the expression of genes involved in the key pathways governing cancer development and progression. They represent ideal targets for personalized cancer therapies and if appropriately designed they can provide specific, non-toxic and effective therapeutic tools. The identification of novel therapeutic ncRNAs and the design of their appropriate formulation is a key aspect for their clinical applicability. RISE- cONCReTE aims to form an international and inter-sectoral network of organizations working on a joint research programme on the development of a safe ncRNA-based drug. RISE- cONCReTE teams up experts in the fields of Molecular Oncology, Epigenetics, Signal transduction, Animal models, Therapeutic delivery and Imaging, business, and education. The participants will exchange skills, knowledge and staff members that will be exposed to synergetic and complementary research environments. RISE- cONCReTE will undertake an integrated approach to reveal novels functional links between ncRNAs and oncogenic pathways. We will: a) characterize novel classes of tumor-associated ncRNAs; b) investigate the impact of ncRNAs on key aspects of tumor cell biology; c) develop cargoes (e.g. aptamers) for delivering therapeutic ncRNA derivatives into specific cancer cell types. By using innovative in vivo imaging tools, we will monitor the accumulation of target ncRNAs in cancer cells and evaluate their biological efficacy in inhibiting the growth and spreading of malignant tumors. The resulting approaches will provide stable and effective tools thus potentially improving the quality of life (QOL) of the cancer patients. Further, the joint research and training programme of RISE- cONCReTE will be performed in academic institutions and SME to provide a unique interdisciplinary platform for scientists with a significant contribution to EU competitiveness.

Original text from CORDIS.

Participants

UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II · NapoliCoordinatorItaly
ASSOCIAZIONE HAND IN HAND · NemiItaly
CLINICA MEDITERRANEA SPA · NapoliItaly
CONSIGLIO NAZIONALE DELLE RICERCHE · RomaItaly
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM · RotterdamNetherlands
FUNDACIO INSTITUT DE RECERCA CONTRA LA LEUCEMIA JOSEP CARRERAS · BadalonaSpain
FUNDACION PARA LA INVESTIGACION MEDICA APLICADA FIMA · PamplonaSpain
JENACELL GMBH · JENAGermany
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN · PlaneggGermany
PERCUROS BV · 's-Gravenhage (Den Haag)Netherlands
PROGREDUM GMBH · KaiserslauternGermany
RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITAT BONN · BonnGermany
TACIT BIO INNOVATION LIMITED · Sutton ColdfieldUnited Kingdom
TECOBIOSCIENCES GMBH · LANDSHUTGermany
UNIVERSITAET INNSBRUCK · InnsbruckAustria
UNIVERSITATEA DE MEDICINA SI FARMACIE IULIU HATIEGANU CLUJ-NAPOCA · Cluj-NapocaRomania
XENOPAT SL · HOSPITALET DE LLOBREGATSpain

cONCReTE · DevelOpmeNt of Cancer RNA TherapEutics

Project objective

Participants

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