CLONESA · Closed Loop NeuroStimulation of Attention
Horizon 2020 — Marie Skłodowska-Curie Actions
- Duration
- 2020-09-01 → 2023-01-02
- EU contribution
- €184,708
- Participants
- 1
- Scheme
- MSCA-IF
Lines connect the coordinator with its partners.
Results in brief
Closed Loop NeuroStimulation of Attention
Have you ever found yourself lost in thought, unable to focus on the task at hand? This common experience is known as mind-wandering, and it can negatively impact cognitive control and performance, leading to issues in various domains such as education and driving. Mind-wandering can also have far-reaching effects on mental health, particularly in conditions like depression and Alzheimer's disease. The aim of this project was to understand the nature of mind-wandering as a cognitive state and its underlying neural mechanisms. By exploring the complex processes involved in mind-wandering, the research sought to develop strategies for reducing maladaptive forms of mind-wandering and increasing beneficial ones. The proposal also aimed to examine the potential for non-invasive brain stimulation to regulate the neurocognitive markers of executive control during mind-wandering and improve cognitive control. The proposal is important for society as it could lead to significant advancements in the field of cognitive and clinical neuroscience. By identifying markers for mind-wandering, we could develop interventions to reduce maladaptive forms and increase beneficial ones. Moreover, the findings could inform the use of neurostimulation in managing conditions such as depression and Alzheimer's disease. The overall objectives were to investigate the neurocognitive markers of executive control during mind-wandering and explore the potential for non-invasive brain stimulation to regulate these markers for improving cognitive control.
Data: CORDIS, © European Union
Project objective
It is estimated that we spend up to 50% of our waking hours lost in thought and although mind-wandering (MW) has been associated with adaptive features of cognition such as creativity, it has also been linked with maladaptive patterns of thought that lead to states of reduced attention that can affect safety, learning and mental health. The level of intentionality with which MW is pursued has recently been identified as a key moderating factor between beneficial and detrimental consequences, and has been linked to the thickness of the prefrontal cortex as well as disorders of attention. Non-invasive brain stimulation (NIBS) to this structure has been shown to modulate the underlying neurocognitive processes of executive control with the potential of correcting the trajectory of maladaptive patterns of activity and the promise to improve attention in health and disease. However, the potential of NIBS to restore and improve brain functions has been challenged by the inter- and intraindividual variability in the response to neurostimulation. CLONESA seeks to identify the individual neurocognitive markers of attention and optimal neurostimulation parameters for the development of a “closed-loop” system able to assess and modulate neural patterns of activity in real time for prospective use in a plug n’ play device for precision medicine. These patterns will be detected with EEG-based neuroadaptive systems (NAS) during tests of sustained attention and the optimal alpha-tACS parameters will be identified with Bayesian optimization. Lastly, the findings will be implemented and tested on a large scale with a commercial closed-loop neurostimulation device for a rapid translation of neuroscientific research to personalized interventions towards cognitive enhancement and treatment of attentional disorders. The present action will pioneer the intersection of NAS, NIBS and translational research for the benefit of healthy and clinical populations.
Original text from CORDIS.
Participants
- INSTITUT DU CERVEAU ET DE LA MOELLE EPINIERE · ParisCoordinatorFrance
Links
Data: CORDIS, © European Union